Aftin-5

CHF 75.00
In stock
AG-MR-C0015-M0011 mgCHF 75.00
AG-MR-C0015-M0055 mgCHF 300.00
AG-MR-C0015-M02525 mgCHF 840.00
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Product Details
Synonyms (2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol; Amyloidβ Forty-Two Inducer 5
Product Type Chemical
Properties
Formula

C19H26N6O

MW 354.5
CAS 1461717-05-4
Purity Chemicals ≥98% (NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO or ethanol.
Reconstitution Stock solutions can be made up to 10mM in DMSO.
Identity Determined by 1H-NMR.
InChi Key HYFZLABHJHEEFS-CQSZACIVSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Roscovitine-related purine with no activity on CDKs (used as control for roscovitine).
  • Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable.
  • Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation.
  • Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
  • Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds).
Product References
  1. Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action: K. Bettayeb, et al.; FASEB J. 26, 5115 (2012)
  2. Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?: A. Hochard, et al.; J. Alzheimers Dis. 35, 107 (2013)
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