Aftin-5

More Information
Product Details
Synonyms	(2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol; Amyloidβ Forty-Two Inducer 5
Product Type	Chemical
Properties
Formula	C₁₉H₂₆N₆O
MW	354.5
CAS	1461717-05-4
Purity Chemicals	≥98% (NMR)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO or ethanol.
Reconstitution	Stock solutions can be made up to 10mM in DMSO.
Identity	Determined by ¹H-NMR.
InChi Key	HYFZLABHJHEEFS-CQSZACIVSA-N
Smiles	CC[C@H](CO)NC1=NC2=C(N=CN2C(C)C)C(=N1)N(C)C1=CC=CC=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Roscovitine-related purine with no activity on CDKs (used as control for roscovitine).
Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable.
Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation.
Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds).

Product References

Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action: K. Bettayeb, et al.; FASEB J. 26, 5115 (2012)
Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?: A. Hochard, et al.; J. Alzheimers Dis. 35, 107 (2013)
A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens: G. Esposito, et al.; Marine Drugs 17, E472 (2019)

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