MOTS-c (K14Q Mutant) (human)

CHF 180.00
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AG-CP3-0033-M0011 mgCHF 180.00
AG-CP3-0033-M0055 mgCHF 630.00
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Product Details
Synonyms H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Gln-Leu-Arg-OH . TFA; Mitochondrial Open Reading Frame of the 12S rRNA-c K14Q Mutant; MOTS3 K14Q Mutant
Product Type Chemical
Properties
Formula

C100H148N28O23S2 . C2HF3O2

MW 2174.6 . 114.0
Sequence

H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Gln-Leu-Arg-OH

Source/Host Chemicals Synthetic.
Purity Chemicals ≥95% (HPLC)
Appearance Solid lyophilized powder.
Solubility Soluble in water.
Crossreactivity Human
InChi Key DXUYVBXOAGWAKV-JBICZICZSA-N
Smiles [H]N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)CC3=CC=CC=C3)=O)[C@@H](C)CC)=O)CC4=CC=C(O)C=C4)=O)=O)CCSC)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)=O)CCSC.O=C(O)C(F)(F)F
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • The mitochondria-derived peptide (MDP) MOTS-c promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). It induces cellular and systemic glucose uptake and improves insulin sensitivity and has been shown to prevent diet-induced obesity (DIO) in mice.
  • This K14Q mutant of MOTS-c has been shown to be associated with exceptional longevity and may be interesting for aging research.
Product References
  1. A mitochondrially encoded hormone ameliorates obesity and insulin resistance: K. Zarse & M. Ristow; Cell. Metab. 21, 355 (2015)
  2. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance: C. Lee, et al.; Cell. Metab. 21, 443 (2015)
  3. The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? N. Fuku, et al.; Aging Cell 14, 921 (2015)
  4. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism: C. Lee, et al.; Free Radic. Biol. Med. 100, 182 (2016)
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