MOTS-c (K14Q Mutant) (human)

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Product Details
Synonyms	H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Gln-Leu-Arg-OH . TFA; Mitochondrial Open Reading Frame of the 12S rRNA-c K14Q Mutant; MOTS3 K14Q Mutant
Product Type	Chemical
Properties
Formula	C₁₀₀H₁₄₈N₂₈O₂₃S₂ . C₂HF₃O₂
MW	2174.6 . 114.0
Sequence	H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Gln-Leu-Arg-OH
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥95% (HPLC)
Appearance	Solid lyophilized powder.
Solubility	Soluble in water.
Crossreactivity	Human
InChi Key	DXUYVBXOAGWAKV-JBICZICZSA-N
Smiles	[H]N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)CC3=CC=CC=C3)=O)[C@@H](C)CC)=O)CC4=CC=C(O)C=C4)=O)=O)CCSC)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)=O)CCSC.O=C(O)C(F)(F)F
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

The mitochondria-derived peptide (MDP) MOTS-c promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). It induces cellular and systemic glucose uptake and improves insulin sensitivity and has been shown to prevent diet-induced obesity (DIO) in mice.
This K14Q mutant of MOTS-c has been shown to be associated with exceptional longevity and may be interesting for aging research.

Product References

A mitochondrially encoded hormone ameliorates obesity and insulin resistance: K. Zarse & M. Ristow; Cell. Metab. 21, 355 (2015)
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance: C. Lee, et al.; Cell. Metab. 21, 443 (2015)
The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? N. Fuku, et al.; Aging Cell 14, 921 (2015)
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism: C. Lee, et al.; Free Radic. Biol. Med. 100, 182 (2016)

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