AdipoGen Life Sciences

MOTS-c (human)

CHF 180.00
In stock
AG-CP3-0026-M0011 mgCHF 180.00
AG-CP3-0026-M0055 mgCHF 630.00
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Product Details
Synonyms H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH . TFA; Mitochondrial Open Reading Frame of the 12S rRNA-c; MOTS3
Product Type Chemical
Properties
Formula

C101H152N28O22S2 . C2HF3O2

MW 2174.6 . 114.0
Sequence

H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH

CAS 1627580-64-6
Source/Host Chemicals Synthetic.
Purity Chemicals ≥95% (HPLC)
Appearance White lyophilized powder.
Solubility Soluble in water.
Crossreactivity Human
InChi Key JLKDYZLVBJDJTO-DNWXONKHSA-N
Smiles OC(=O)C(F)(F)F.[H]N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Mitochondria-derived peptide (MDP).
  • Promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK).
  • Induces cellular and systemic glucose uptake and improves insulin sensitivity. Shown to prevent diet-induced obesity (DIO) in mice.
  • Potential anti-obesity and anti-aging compound.
  • Involved in cellular stress resistance by regulating the nuclear genome. During metabolic stress (serum or glucose deprivation or oxidative stress) translocates to the nucleus in an AMPK-dependent manner. In the nucleus, MOTS-c binds to the transcription factor NRF2 which is a stress-responsive transcription factor and activates anti-oxidative stress genes.
  • MOTS-c has been described as a biomarker for monitoring the progression of Hepatitis B virus infection and as an effective antiviral treatment for patients with chronic hepatitis B.
Product References
  1. A mitochondrially encoded hormone ameliorates obesity and insulin resistance: K. Zarse & M. Ristow; Cell. Metab. 21, 355 (2015)
  2. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance: C. Lee, et al.; Cell. Metab. 21, 443 (2015)
  3. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress: K.H. Kim, et al.; Cell Metab. 28, 516 (2018) 
  4. The Mitochondrial-Derived Peptide MOTS-c Attenuates Oxidative Stress Injury and the Inflammatory Response of H9c2 Cells Through the Nrf2/ARE and NF-κB Pathways: C. Shen, et al.; Cardiovasc. Eng. Technol. 13, 651 (2022)
  5. Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection: C. Lin, et al.; Gut (epub ahead of print) 2023
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