KN-93 (water soluble)
AG-CR1-0065-M0011 mgCHF 55.00
AG-CR1-0065-M0055 mgCHF 150.00
AG-CR1-0065-M02525 mgCHF 450.00
|Formula||C26H29ClN2O4S . H3PO4|
|MW||501.0 . 98.0|
|CAS||1188890-41-6 | 139298-40-1 (free base)|
|Purity Chemicals||≥98% (HPLC)|
|Appearance||White to off-white solid.|
|Solubility||Soluble in water.|
|Other Product Data||Stock solutions are stable for up to 3 months when stored at -20°C.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Protect from light.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Selective Ca2+/calmodulin-dependent protein kinase II inhibitor .
- Insulin release inhibitor .
- Acid secretion inhibitor .
- G1 cell cycle arrest inducer .
- Apoptosis inducer [4, 7].
- Ion channel inhibitor [5, 6].
- ROS inducer .
- Androgen receptor inhibitor .
- The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991)
- Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC& 191, 255 (1993)
- Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993)
- G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995)
- CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels: L. Gao, et al.; BBRC 345, 1606 (2006)
- KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels: S. Reazadeh, et al.; J. Pharmacol. Exp. Ther. 317, 292 (2006)
- KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer: O.W. Rokhlin, et al.; Cancer Biol. Ther. 9, 224 (2010)