KN-93 (water soluble)

CHF 55.00
In stock
AG-CR1-0065-M0011 mgCHF 55.00
AG-CR1-0065-M0055 mgCHF 150.00
AG-CR1-0065-M02525 mgCHF 450.00
 
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Product Details
Synonyms 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
Product Type Chemical
Properties
Formula C26H29ClN2O4S . H3PO4
MW 501.0 . 98.0
CAS 1188890-41-6 | 139298-40-1 (free base)
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in water.
Other Product Data Stock solutions are stable for up to 3 months when stored at -20°C.
InChi Key LHFKHAVGGJJQFF-UEOYEZOQSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Hygroscopic.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Selective Ca2+/calmodulin-dependent protein kinase II inhibitor [1].
  • Insulin release inhibitor [2].
  • Acid secretion inhibitor [3].
  • G1 cell cycle arrest inducer [4].
  • Apoptosis inducer [4, 7].
  • Ion channel inhibitor [5, 6].
  • ROS inducer [7].
  • Androgen receptor inhibitor [7].
Product References
  1. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991)
  2. Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC& 191, 255 (1993)
  3. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993)
  4. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995)
  5. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels: L. Gao, et al.; BBRC 345, 1606 (2006)
  6. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels: S. Reazadeh, et al.; J. Pharmacol. Exp. Ther. 317, 292 (2006)
  7. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer: O.W. Rokhlin, et al.; Cancer Biol. Ther. 9, 224 (2010)
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