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AdipoGen Life Sciences
KN-93 (water soluble)
30
CHF
CHF 30.00
In stock
AG-CR1-0065-M0011 mgCHF 30.00
AG-CR1-0065-M0055 mgCHF 125.00
AG-CR1-0065-M02525 mgCHF 375.00
| Product Details | |
|---|---|
| Synonyms | 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H29ClN2O4S . H3PO4 |
| MW | 501.0 . 98.0 |
| CAS | 1188890-41-6 | 139298-40-1 (free base) |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water. |
| Other Product Data |
Stock solutions are stable for up to 3 months when stored at -20°C. |
| InChi Key | LHFKHAVGGJJQFF-UEOYEZOQSA-N |
| Smiles | OP(O)([O-])=O.COC1=CC=C(C=C1)S(=O)(=O)N(CCO)C1=C(C[NH+](C)C\C=C\C2=CC=C(Cl)C=C2)C=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective Ca2+/calmodulin-dependent protein kinase II inhibitor [1].
- Insulin release inhibitor [2].
- Acid secretion inhibitor [3].
- G1 cell cycle arrest inducer [4].
- Apoptosis inducer [4, 7].
- Ion channel inhibitor [5, 6].
- ROS inducer [7].
- Androgen receptor inhibitor [7].
Product References
- The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991)
- Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC& 191, 255 (1993)
- Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993)
- G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995)
- CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels: L. Gao, et al.; BBRC 345, 1606 (2006)
- KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels: S. Reazadeh, et al.; J. Pharmacol. Exp. Ther. 317, 292 (2006)
- KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer: O.W. Rokhlin, et al.; Cancer Biol. Ther. 9, 224 (2010)