DLL1 (mouse):Fc (human) (rec.)

CHF 195.00
In stock
AG-40A-0148Y-C01010 µgCHF 195.00
AG-40A-0148Y-C05050 µgCHF 390.00
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Product Details
Synonyms Delta-like Protein 1; Delta 1
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence Extracellular domain of mouse DLL1 (aa 18-545) is fused at the C-terminus to the Fc portion of human IgG1.
Crossreactivity Mouse
Specificity Interacts with Notch receptors.
Biological Activity Inhibits adipogenesis of 3T3L-1 cells. Induces Hes-1 in 3T3L-1 cells.
MW ~100kDa (SDS-PAGE)
Purity ≥90% (SDS-PAGE)
Endotoxin Content <0.1EU/μg purified protein (LAL test; Lonza).
Concentration After reconstitution:
for 10µg size: 0.1mg/ml
for 50µg size: 1 mg/ml
Reconstitution 10µg size: Reconstitute with 100µl sterile water.
50µg size: Reconstitute with 50µl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data Uniprot link Q61483: DLL1 (mouse)
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumor progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK cell precursor.

Product References
  1. Flt-1 (Vascular Endothelial Growth Factor Receptor-1) Is Essential for the Vascular Endothelial Growth Factor-Notch Feedback Loop During Angiogenesis: J.C. Chappell, et al.; Arterioscler. Thromb. Vasc. Biol. 33, 1952 (2013)
  2. Mimicking The Stem Cell Niche In Diseased Muscle With A Notch Activator-conjugated 3d-construct: X. Mu, et al.; ORS Annual Meeting Transactions Presentation (2014)
  3. Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9High Committed Megakaryocytic Progenitors: M. Weiss-Gayet, et al.; PLoS One 11, e0153860 (2016)
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