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FNDC4 (human) ELISA Kit
680
CHF
CHF 680.00
In stock
AG-45B-0028-KI0196 wellsCHF 680.00
Figure 1: Standard curve
| Product Details | |
|---|---|
| Synonyms | Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1; Fc Soluble FNDC4; FcsFNDC4 |
| Product Type | Kit |
| Properties | |
| Application Set | Quantitative ELISA |
| Specificity |
Detects human FNDC4 in serum, plasma and cell culture supernatant. It cross-reacts with mouse, rat, monkey and dog FNDC4. It does not cross-react with human, mouse or rat FNDC5 / Irisin. |
| Crossreactivity |
Dog Human Monkey Mouse Rat |
| Quantity |
1 x 96 wells |
| Sensitivity | 40pg/ml |
| Range | 0.078 to 5ng/ml |
| Sample Type |
Cell Culture Supernatant Plasma Serum |
| Assay Type | Sandwich |
| Detection Type | Colorimetric |
| Other Product Data |
UniProt link Q9H6D8: FDNC4 (human) |
| Accession Number | Q9H6D8 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use. |
| Use/Stability | 12 months after the day of manufacturing. See expiry date on ELISA Kit box. |
| Documents | |
| Manual |
 Download PDF |
| MSDS |
Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes. FNDC4 is a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.
Recently, a new role of FNDC4 as a hepatokine has been published. Liver primarily controls the circulating levels of FNDC4 showing tight correlation with insulin sensitivity. In addition, a new orphan adhesion G protein-coupled receptor 116 (GPR116) has been identified as a receptor of FNDC4 in white adipose tissue (WAT), thereby establishing an endocrine FNDC4-GPR116 axis in the control of systemic glucose homeostasis. Moreover, the FNDC4-GPR116 axis is impaired in diabetic patients and therapeutic injections of recombinant Fc-FNDC4 into pre-diabetic mice corrected pre-diabetic hyperglycemia.
FNDC4 is a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases and is a potential biomarker for different inflammatory, metabolic diseases as well as some cancers (e.g. Glioblastoma).
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