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AdipoGen Life Sciences
Irisin (rec.) (untagged) (E.coli)
210
CHF
CHF 210.00
In stock
AG-40B-0103-C01010 µgCHF 210.00
AG-40B-0103-30103 x 10 µgCHF 420.00
| Product Details | |
|---|---|
| Synonyms | Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved) |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence |
Irisin (human, aa 32-143 / mouse, aa 29-140) is untagged. Irisin has 100% identity between mouse, rat, monkey and human. |
| Crossreactivity |
Human Mouse |
| MW | ~12kDa |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg purified protein (LAL test; Lonza). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized from PBS. |
| Other Product Data |
Uni-Prot link Q8NAU1: FNDC5 [Irisin] |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
Product References
- The myokine irisin increases cortical bone mass: G. Colaianni, et al.; PNAS 112, E5763 (2015)
- The myokine irisin is released in response to saturated atty acids and promotes pancreatic beta-cell survival and insulin secretion: A. Natalicchio, et al.; Diabetes 66, 2849 (2017)
- DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone: C.E. Metzger, et al.; Sci. Rep. 9, 15144 (2019)
- Irisin Prevents Disuse-Induced Osteocyte Apoptosis: G. Storlino, et al.; J. Bone Miner. Res. 35, 766 (2020)
- The Myokine Irisin Promotes Osteogenic Differentiation of Dental Bud-Derived MSCs: F. Posa, et al.; Biology 10, 295 (2021)
- Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice: P. Pignataro, et al.; Int. J. Mol. Sci. 23, 14 (2022)
- Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing: A. Oranger, et al.; Int. J. Mol. Sci. 24, 1809 (2023)
- Irisin Role in Chondrocyte 3D Culture Differentiation and Its Possible Applications: F. Posa, et al.; Pharmaceutics 15, 585 (2023)
- Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament: Y. Yang, et al.; Eur. J. Orthod. XX, 1 (2023)
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