AdipoGen Life Sciences

anti-Irisin, pAb (IN102)

CHF 460.00
In stock
AG-25B-0027-C100100 µgCHF 460.00
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Product Details
Synonyms Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved)
Product Type Polyclonal Antibody
Properties
Source/Host Rabbit
Immunogen/Antigen Recombinant irisin.
Application

Western Blot: (1:1'000)

Crossreactivity Human
Monkey
Mouse
Rat
Specificity

Recognizes human, mouse, rat, monkey Irisin and FNDC5. Detects endogenous mouse and human Irisin [Lit: 1-2].

Purity Detail Epitope-affinity purified.
Concentration Lot dependent.
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Isotype Negative Control

Rabbit IgG

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

Product References
  1. Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway: C.D. Wrann, et al.; Cell Metab. 18, 649 (2013)
  2. Detection and quantitation of circulating human irisin by tandem mass spectrometry: M.P. Jedrychowski, et al.; Cell Metab. 22, 734 (2015)
  3. Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis: X. Li, et al.; Front. Cell Dev. Biol. 9, 703670 (2021)
  4. AAV-mediated skeletal muscle specific irisin expression does not contribute to weight loss in mice: BB. Bagon, et al.; BBRC 682, 111 (2023)
  5. Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice: N.H. Witmer, et al.; Cell Metab. 36, 879 (2024)
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