AdipoGen Life Sciences

Irisin (rec.) (HEK293)

CHF 220.00

In stock

AG-40B-0102-C01010 µgCHF 220.00

AG-40B-0102-30103 x 10 µgCHF 440.00

More Information
Product Details
Synonyms	Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved)
Product Type	Protein
Properties
Source/Host	HEK 293 cells
Sequence	Irisin (human, aa 32-143 /mouse, aa 29-140) is FLAG^®-tagged at the N-terminus. Irisin has 100% identity between mouse, rat, monkey and human. Monomeric. Purified by Size Exclusion Chromatography (SEC).
Crossreactivity	Human Mouse
MW	~26kDa
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.1EU/μg purified protein (LAL test; Lonza).
Concentration	0.1mg/ml after reconstitution.
Reconstitution	Reconstitute with 100μl sterile water.
Formulation	Lyophilized. Contains PBS.
Other Product Data	Uni-Prot link Q8NAU1: Irisin FLAG is a registered trademark of Sigma-Aldrich Co.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

This protein is purified by size exclusion chromatography (SEC) and contains only the monomeric form and no aggregates.

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