Irisin:Fc (human) (rec)

CHF 190.00
In stock
AG-40B-0115-C01010 µgCHF 190.00
AG-40B-0115-50105 x 10 µgCHF 570.00
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Product Details
Synonyms Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved)
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence Irisin (human, aa 32-143 /mouse, aa 29-140) is fused at the C-terminus to the Fc portion of human IgG1. Irisin has 100% identity between mouse, rat, monkey and human.
Crossreactivity Human
Monkey
Mouse
Rat
MW ~50kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration 0.1mg/ml after reconstitution.
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data Uni-Prot link Q8NAU1: Irisin

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

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