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AdipoGen Life Sciences
FNDC5:Fc (human) (rec.)
290
CHF
CHF 290.00
In stock
AG-40B-0153-C01010 µgCHF 290.00
AG-40B-0153-30103 x 10 µgCHF 575.00
| Product Details | |
|---|---|
| Synonyms | Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2. |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human. |
| Crossreactivity |
Human Mouse Rat |
| MW | ~52kDa |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
Uni-Prot link Q8NAU1: FNDC5 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Irisin is a recently described exercise and PGC1-α-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).
Product References
- FNDC5 is produced in the stomach and associated to body composition: S. Barja-Fernandez, et al.; Sci. Rep. 6, 23067 (2016)
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