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AdipoGen Life Sciences
Pseudouridimycin
170
CHF
CHF 170.00
In stock
AG-CN2-0316-M0011 mgCHF 170.00
AG-CN2-0316-M0055 mgCHF 680.00
| Product Details | |
|---|---|
| Synonyms | PUM |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H26N8O9 |
| MW | 486.4 |
| CAS | 1566586-52-4 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥85% (HPLC) |
| Appearance | Off-white to yellow powder. |
| Solubility | Soluble in DMSO or water. |
| Identity | Determined by 1H-NMR and MS. |
| Declaration | Manufactured by Naicons Srl. |
| InChi Key | XDEYHXABZOKKDZ-YFKLLHAASA-N |
| Smiles | O[C@H]1[C@H](C(C(N2)=O)=CNC2=O)O[C@H](CNC([C@H](CCC(N)=O)N(O)C(CNC(N)=N)=O)=O)[C@H]1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Peptidyl nucleoside antibiotic.
- Selective nucleoside-analog inhibitor of bacterial RNA polymerase (RNAP). Inhibits RNAP through a distinctive binding site on RNAP (the NTP addition site) and mechanism (competition with UTP for occupancy of the NTP addition site) compared to rifampin.
- Targets bacterial RNAP in Gram-positive and Gram-negative organisms, including antibiotic-resistant isolates and shows extremely low frequency of resistance selection.
- Potently inhibits bacterial RNAP in vitro, inhibits bacterial growth in culture and has shown in vivo efficacy in animal models of infection.
Product References
- Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase: S.I. Maffioli, et al.; Cell 169, 1240 (2017)
- Pseudouridimycin: The First Nucleoside Analogue That Selectively Inhibits Bacterial RNA Polymerase: M.F. Chellat & R. Riedl; Angew. Chem. Int. Ed. Engl. 56, 13184 (2017)
- Novel RNA polymerase inhibitor found in soil extracts provides hope for future antibacterial drugs: R.H. Ebright; Future Med. Chem. 9, 1857 (2017)
- A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery: L-M. Wee, et al.; Cell 186, 1244 (2023)
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