AdipoGen Life Sciences


CHF 170.00
In stock
AG-CN2-0316-M0011 mgCHF 170.00
AG-CN2-0316-M0055 mgCHF 680.00
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Product Details
Synonyms PUM
Product Type Chemical


MW 486.4
CAS 1566586-52-4
Source/Host Chemicals Isolated from Streptomyces sp.
Purity Chemicals ≥85% (HPLC)
Appearance Off-white to yellow powder.
Solubility Soluble in DMSO or water.
Identity Determined by 1H-NMR and MS.
Declaration Manufactured by Naicons Srl.
Smiles O[C@H]1[C@H](C(C(N2)=O)=CNC2=O)O[C@H](CNC([C@H](CCC(N)=O)N(O)C(CNC(N)=N)=O)=O)[C@H]1O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Protect from light when in solution.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Peptidyl nucleoside antibiotic.
  • Selective nucleoside-analog inhibitor of bacterial RNA polymerase (RNAP). Inhibits RNAP through a distinctive binding site on RNAP (the NTP addition site) and mechanism (competition with UTP for occupancy of the NTP addition site) compared to rifampin.
  • Targets bacterial RNAP in Gram-positive and Gram-negative organisms, including antibiotic-resistant isolates and shows extremely low frequency of resistance selection.
  • Potently inhibits bacterial RNAP in vitro, inhibits bacterial growth in culture and has shown in vivo efficacy in animal models of infection.
Product References
  1. Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase: S.I. Maffioli, et al.; Cell 169, 1240 (2017)
  2. Pseudouridimycin: The First Nucleoside Analogue That Selectively Inhibits Bacterial RNA Polymerase: M.F. Chellat & R. Riedl; Angew. Chem. Int. Ed. Engl. 56, 13184 (2017)
  3. Novel RNA polymerase inhibitor found in soil extracts provides hope for future antibacterial drugs: R.H. Ebright; Future Med. Chem. 9, 1857 (2017)
  4. A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery: L-M. Wee, et al.; Cell 186, 1244 (2023)
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