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AdipoGen Life Sciences
Rifamycin AF-API
110
CHF
CHF 110.00
In stock
AG-CN2-0325-M01010 mgCHF 110.00
AG-CN2-0325-M05050 mgCHF 440.00
| Product Details | |
|---|---|
| Synonyms | Rifamycin AF/API; NCI-143-448; NSC 143448; Rifazacyclo-6; 3-Piperidinoiminomethylrifamycin; Rifaldehyde o-tolylimine |
| Product Type | Chemical |
| Properties | |
| Formula |
C43H57N3O12 |
| MW | 807.9 |
| CAS | 13292-40-5 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Red powder. |
| Solubility | Soluble in DMSO, aqueous acetonitrile or ethanol. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | AUAQTSZMQWNWJC-LFNXVMJESA-N |
| Smiles | OC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)[C@H](/C=C/O2)OC)OC(C)=O)O)=O)C(/C=N/N3CCCCC3)=C(O)C4=C5C(O[C@@]2(C)C5=O)=C(C)C(O)=C41 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Ansamycin antibiotic.
- Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
- Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections.
Product References
- Rifamycin antibiotics: inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerases from human normal and leukemic lymphoblasts: S.S. Yang, et al.; J. Natl. Cancer Inst. 49, 7 (1972)
- Rifamycin Derivatives Strongly Inhibiting RNA>DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses: C. Gurgo, et al.; J. Natl. Cancer Inst. 49, 61 (1972)
- QSAR Modeling of Antimycobacterial Activity and Activity Against Other Bacteria of 3-Formyl Rifamycin SV Derivatives: D. Dimov, et al.; Quant. Struct.-Act. Relat. 20, 298 (2001)
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