Rifamycin AF

CHF 90.00
In stock
AG-CN2-0321-G0011 gCHF 90.00
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Product Details
Synonyms NCI 145-635; 3-Formylrifamycin; 3-Formylrifampicin SV; 3-Formylrifamycin SV; Rifaldehyde
Product Type Chemical


MW 725.8
CAS 13292-22-3
Source/Host Chemicals Semisynthetic.
Purity Chemicals ≥95% (HPLC)
Appearance Red powder.
Solubility Soluble in DMSO, aqueous acetonitrile or ethanol.
Identity Determined by 1H-NMR and MS.
Smiles OC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)[C@H](/C=C/O2)OC)OC(C)=O)O)=O)C(C([H])=O)=C(O)C3=C4C(O[C@@]2(C)C4=O)=C(C)C(O)=C31
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Protect from light when in solution.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Ansamycin antibiotic.
  • Intermediate of rifampicin.
  • Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
  • Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections.
Product References
  1. Rifamycins: A General View: S. Riva & L.G. Silvestri; Ann. Rev. Microbiol. 26, 199 (1972)
  2. Spin-labeled rifamycin: biological activity: Z.Z. Raykov, et al.; Pharmazie 63, 61 (2008)
  3. New anti-tuberculosis agents amongst known drugs: K.A.E. Lougheed, et al.; Tuberculosis 89, 364 (2009)
  4. The effect of complexation of 3-formylrifamycin SV macrocyclic ether derivatives with metal cations and small nitrogen-containing organic molecules on antibacterial activity against S. aureus and S. epidermidis: P. Przybylski, et al.; Bioorg. Med. Chem. Lett. 25, 3903 (2015)
  5. Rifamycin antibiotics - new compounds and synthetic methods. Part 4: Study of the reaction of 3-formylrifamycin SV with secondary amines and ketones: K. Bujnowski, et al.; Tetrahedr. 71, 158 (2015)
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