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AdipoGen Life Sciences
Rifamycin AF
90
CHF
CHF 90.00
In stock
AG-CN2-0321-G0011 gCHF 90.00
AG-CN2-0321-G0055 gCHF 360.00
AG-CN2-0321-G01010 gCHF 660.00
| Product Details | |
|---|---|
| Synonyms | NCI 145-635; 3-Formylrifamycin; 3-Formylrifampicin SV; 3-Formylrifamycin SV; Rifaldehyde |
| Product Type | Chemical |
| Properties | |
| Formula |
C38H47NO13 |
| MW | 725.8 |
| CAS | 13292-22-3 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Red powder. |
| Solubility | Soluble in DMSO, aqueous acetonitrile or ethanol. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | BBNQHOMJRFAQBN-LXFNAIAASA-N |
| Smiles | OC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)[C@H](/C=C/O2)OC)OC(C)=O)O)=O)C(C([H])=O)=C(O)C3=C4C(O[C@@]2(C)C4=O)=C(C)C(O)=C31 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Ansamycin antibiotic.
- Intermediate of rifampicin.
- Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
- Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections.
Product References
- Rifamycins: A General View: S. Riva & L.G. Silvestri; Ann. Rev. Microbiol. 26, 199 (1972)
- Spin-labeled rifamycin: biological activity: Z.Z. Raykov, et al.; Pharmazie 63, 61 (2008)
- New anti-tuberculosis agents amongst known drugs: K.A.E. Lougheed, et al.; Tuberculosis 89, 364 (2009)
- The effect of complexation of 3-formylrifamycin SV macrocyclic ether derivatives with metal cations and small nitrogen-containing organic molecules on antibacterial activity against S. aureus and S. epidermidis: P. Przybylski, et al.; Bioorg. Med. Chem. Lett. 25, 3903 (2015)
- Rifamycin antibiotics - new compounds and synthetic methods. Part 4: Study of the reaction of 3-formylrifamycin SV with secondary amines and ketones: K. Bujnowski, et al.; Tetrahedr. 71, 158 (2015)
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