Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Jak/Src Inhibitor 1 . hydrochloride
150
CHF
CHF 150.00
In stock
AG-CR1-3647-M0011 mgCHF 150.00
| Product Details | |
|---|---|
| Synonyms | Debio 0617B . HCl; N-(4-Chloro-3-(2-((4-(methyl-carbamoyl)phenyl)amino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)phenyl)-4-(trifluoromethyl)picolinamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C28H23ClF3N7O2 . HCl |
| MW | 582.0 . 36.5 |
| CAS | 1332329-27-7 (parent) |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | VQUNOHCOLZKQJY-UHFFFAOYSA-N |
| Smiles | O=C(NC)C(C=C1)=CC=C1NC2=NC=C3C(CCN(C4=CC(NC(C5=NC=CC(C(F)(F)F)=C5)=O)=CC=C4Cl)C3)=N2.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Multi-kinase inhibitor with potent antiproliferative anti-migratory activities.
- Potent STAT3/5 inhibitor in vitro and in vivo.
- Combined inhibitor of key kinases phosphorylating STAT3 and STAT5 proteins such as JAK, SRC, ABL families of kinases, and class III/V receptor tyrosine kinases (RTK), including FLT3, c-KIT, CSF1-R, PDGFRs and VEGFRs, in nanomolar range.
Product References
- Debio 0617B inhibits growth of STAT3-driven solid tumors through combined inhibition of JAK, SRC, and class III/V receptor tyrosine kinases: M. Murone, et al.; Mol. Cancer Ther. 15, 2334 (2016)
- The multi-kinase inhibitor Debio 0617B reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells: M. Murone, et al.; Mol. Cancer Ther. (Epub ahead of print) (2017)
Related Products
