Nocodazole

CHF 45.00
In stock
AG-CR1-0019-M0055 mgCHF 45.00
AG-CR1-0019-M01010 mgCHF 70.00
AG-CR1-0019-M02525 mgCHF 125.00
AG-CR1-0019-M05050 mgCHF 230.00
 
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Product Details
Synonyms Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
Product Type Chemical
Properties
Formula C14H11N3O3S
MW 301.3
CAS 31430-18-9
RTECS DD6521000
Purity Chemicals ≥98% (NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO or dimethylformamide; almost insoluble in water.
Identity Determined by 1H-NMR.
InChi Key KYRVNWMVYQXFEU-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
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Product Specification Sheet
Datasheet Download PDF
  • Microtubule inhibitor [1, 2, 4].
  • Antitumor compound [1, 2]. 
  • Mitosis inhibitor [3]. 
  • Arrests the cell cycle at G2/M phase [9]. 
  • Promotes tubulin depolymerization [4]. 
  • Induces fragmentation of the Golgi complex [5]. 
  • Inhibits the T cell antigen receptor [6]. 
  • Stimulates the intrinsic GTPase activity of tubulin [7]. 
  • Activates the JNK/SAPK signaling pathway [8]. 
  • Apoptosis inducer [10, 11]. 
  • Autophagy inhibition through prevention of autophagosome-lysosome fusion.
Product References
  1. R17934-NSC 238159: a new antitumor drug--I. Effect on experimental tumors and factors influencing effectiveness: G. Atassi and H.J. Tagnon; Eur. J. Cancer 11, 599 (1975) 
  2. R17934-NSC238159: a new antitumor drug--II. Effect on mitotic cycle of L1210 leukemia cells in vivo and synergism with cytosine arabinoside (NSC63878): G. Atassi, et al.; Eur. J. Cancer 11, 609 (1975) 
  3. Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis; M.A. Jordan, et al.; J. Cell Sci. 102, 401 (1992) 
  4. Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro: R.J. Vasquez, et al.; Mol. Biol. Cell 8, 973 (1997) 
  5. Recycling of golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering: B. Storrie, et al.; J. Cell Biol. 143, 1505 (1998)
  6. Nocodazole inhibits signal transduction by the T cell antigen receptor: R.D. Huby, et al.; J. Biol. Chem. 273, 12024 (1998)
  7. Studies on the nocodazole-induced GTPase activity of tubulin: M.R. Mejillano, et al.; Arch. Biochem. Biophys. 336, 130 (1996) 
  8. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways: T.H. Wang, et al.; J. Biol. Chem. 273, 4928 (1998)
  9. Raf-1/MEK/MAPK pathway is necessary for the G2/M transition induced by nocodazole: C. Hayne, et al.; J. Biol. Chem. 275, 31876 (2000) 
  10. Apoptosis induced by microtubule disrupting drugs in normal murine thymocytes in vitro: V. Bumbasirevic, et al.; Scanning Microsc. 9, 509 (1995) 
  11. Nocodazole induces mitotic cell death with apoptotic-like features in Saccharomyces cerevisiae: K. Endo, et al.; FEBS Lett. 584, 2387 (2010)
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