AdipoGen Life Sciences

anti-NLRP6 (mouse), pAb (IN121)

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AG-25B-0045-C05050 µgCHF 320.00
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Product Details
Synonyms NOD-like Receptor Family Pyrin Domain-containing 6; NACHT, LRR and PYD Domains-containing Protein 6; Angiotensin II/Vasopressin Receptor; PYRIN-containing APAF1-like Protein 5-like
Product Type Polyclonal Antibody
Properties
Source/Host Rabbit
Immunogen/Antigen NLRP6 peptide.
Application

Western Blot: (1:1'000) 

Crossreactivity Mouse
Specificity

Recognizes mouse NLRP6 by Western blot.

Purity ≥95% (SDS-PAGE)
Purity Detail Epitope-affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 0.02% Proclin 300.
Isotype Negative Control

Rabbit IgG

Accession Number Q91WS2
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
Product Specification Sheet
Datasheet Download PDF
Description

NOD-like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD-like receptor (NLR) family, migrating at 100 kDa in western blot, acts as a cytosolic innate immune sensor that recognizes microbe-associated molecular patterns. NLRP6 recruits the adaptor apoptosis-associated speck-like protein (ASC) and the inflammatory caspase-1 or caspase-11 to form an inflammasome, which mediates the maturation and secretion of the pro-inflammatory cytokines IL-18 and IL-1β. In intestinal epithelial cells, the NLRP6 inflammasome functions in regulating gut microbiome composition, and goblet cell function and is involved in susceptibility to gastrointestinal inflammatory, infectious and neoplastic diseases. In the gut, Nlrp6 controls microbiota, maintains epithelial integrity, and regulates metabolic diseases to modulate host defense during microbial infections, cancer protection, and regulation of neuroinflammation. Nlrp6 has also been shown to negatively regulate NF-κB signaling in mouse models. In Nlrp6-/- mice models, serum IL-18 levels are reduced under steady-state conditions and after dextran sulfate sodium (DSS)-induced colitis. The Nlrp6 inflammasome is activated during bacterial infections and the LTA (lipoteichoic acid) from Listeria binds Nlrp6 and activates the Nlrp6 inflammasome via ASC to regulate host defense during Gram-positive bacterial infection. Nlrp6 activates both caspase-1 and caspase-11.

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