DLK1, Soluble (human) ELISA Kit
|Synonyms||Protein Delta Homolog 1; pG2; Fetal Antigen 1; FA 1|
|Application Set||Quantitative ELISA|
Detects human DLK1. Does not cross-react with human DLL1, human DNER or mouse DLK1.
1 x 96 wells
|Range||0.47 to 30ng/ml|
Cell Culture Supernatant
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||+4°C|
After standard reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Plate and reagents should reach room temperature before use.
|Use/Stability||12 months after the day of manufacturing. See expiry date on ELISA Kit box.|
|Product Specification Sheet|
The Notch signaling pathway is essential for appropriate cell differentiation and cell fate decisions. DLK1 (Protein delta homolog 1; Preadipocyte factor 1; Pref-1) is a regulator of adipocyte differentiation found in serum and urine. DLK1 shifts nutrient metabolism towards FA oxidation. Serum or plasma levels of soluble DLK1 affect negatively or positively adipogenesis and control mesenchymal cell fate. DLK1 is frequently upregulated in myelodysplastic syndrome (MDS) patients compared to non-leukemic individuals. Fetus is the source of maternal circulating DLK1 during pregnancy. It has been recently reported that measurement of DLK1 in maternal blood may be a valuable method for diagnosing human disorders associated with impaired DLK1 expression, and to predict poor intrauterine growth and complications of pregnancy.
- Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014)
- Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction: M. Cleaton, et al.; Nat. Genet. 48, 1473 (2016)
- Low Maternal DLK1 Levels at 26 Weeks Is Associated With Small for Gestational Age at Birth: A. Pham, et al.; Front. Endocrinol. 13, 836731 (2022)