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AdipoGen Life Sciences
anti-DLK1 (human), mAb (PF13-3)
300
CHF
CHF 300.00
In stock
AG-20A-0069-C05050 µgCHF 300.00
AG-20A-0069-C100100 µgCHF 390.00
Figure 1: Immunohistochemical staining of DLK1 using anti-DLK1 (human), mAb (PF13-3) (Prod. No. AG-20A-0069) in human adrenal tissue (10µg/ml).
This antibody has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.
This antibody has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.
Figure 2: FACS: DLK1-transfected HEK 293 (Full length) cells were stained significantly using anti-DLK1 (human), mAb (PF13-3) (Prod. No. AG-20A-0069).
Figure 3: Western blot analysis of human DLK-1 [Pref-1] using anti-DLK1 (human), mAb (PF13-3) (Prod. No. AG-20A-0069) at 1: 2,000 dilution.
A.
1. Human DLK-1-Fc protein.
2. Transfected human DLK-1 full length cell lysate (HEK 293).
3. Mock Transfected HEK293 cell lysate.
B.
1. Human DLK-1-Fc protein.
2. Mouse DLK-1-Fc protein.
3. Human DNER-Fc protein.
4. Human DLL1-Fc protein.
5. Human DLL3-Fc protein.
6. Human DLL4-Fc protein.
7. Human Jagged1-Fc protein.
8. Human FGF23-Fc protein.
A.
1. Human DLK-1-Fc protein.
2. Transfected human DLK-1 full length cell lysate (HEK 293).
3. Mock Transfected HEK293 cell lysate.
B.
1. Human DLK-1-Fc protein.
2. Mouse DLK-1-Fc protein.
3. Human DNER-Fc protein.
4. Human DLL1-Fc protein.
5. Human DLL3-Fc protein.
6. Human DLL4-Fc protein.
7. Human Jagged1-Fc protein.
8. Human FGF23-Fc protein.
| Product Details | |
|---|---|
| Synonyms | Protein Delta Homolog 1; Fetal Antigen 1; Preadipocyte Factor 1; Pref-1; FA1 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | PF13-3 |
| Isotype | Mouse IgG1κ |
| Immunogen/Antigen | Recombinant human DLK1 (extracellular domain). |
| Application |
ELISA: (direct or indirect: 1:2'000-1:10'000) |
| Crossreactivity | Human |
| Specificity |
Recognizes human DLK1. Does not cross-react with mouse DLK1. |
| Purity Detail | Protein G-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
The transmembrane and secreted protein delta-like 1 homolog (DLK1; Protein delta homolog 1; Preadipocyte factor 1; Pref-1) belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-α converting enzyme (TACE) to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.
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