Viridicatumtoxin

CHF 240.00
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AG-CN2-0172-M0011 mgCHF 240.00
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Product Details
Synonyms NSC 159628; BRN 2934660; Viridicatumtoxin A
Product Type Chemical
Properties
Formula

C30H31NO10

MW 565.6
CAS 39277-41-3
RTECS ZA4930000
Source/Host Chemicals Isolated from Penicillium brasilianum.
Purity Chemicals ≥95% (HPLC)
Appearance Yellow solid.
Solubility Soluble in ethanol, methanol or DMSO (all 1mg/ml).
InChi Key SUWQGLGDFGHZNH-WBWZXODPSA-N
Smiles OC(C[C@]1(O)[C@@H](O)C2=C(C[C@]34C(C)=CCCC4(C)C)C(C3=C(OC)C=C5O)=C5C(O)=C2C6=O)=C(C(N)=O)C([C@]16O)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Mycotoxin.
  • Tetracycline antibiotic.
  • Potent antibacterial agent with activity against several strains of Staphylococcus aureus, including Methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA).
  • Inhibits bacterial undecaprenyl pyrophosphate (UPP) synthase activity.
  • Modest antitumor agent against selected cancer cell lines (IC50~1µM).
Product References
  1. Viridicatumtoxin, a new mycotoxin from Penicillium viridicatum Westling: R.D. Hutchison, et al.; Toxicol. Appl. Pharmacol. 24, 507 (1973)
  2. Microbial transformations of natural antitumor agents. 20. Glucosylation of Viridicatumtoxin: M.S. Raju, et al.; J. Nat. Prod. 45, 321 (1982)
  3. Viridicatumtoxin mycotoxicosis in mice and rats: A.M. Bendele, et al.; Toxicol. Lett. 22, 287 (1984)
  4. Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11: C.J. Zheng, et al.; J. Antibiot. 61, 633 (2008)
  5. Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold: T. Shang, et al.; J. Org. Chem. 80, 12501 (2015)
  6. Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules: J. Inokoshi, et al.; J. Antibiot. 69,798 (2016)
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