Neuromedin U-25 (human)

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Product Details
Synonyms NMU-25; FRVDEEFQSPFASQSRGYFLFRPRN-NH2 . TFA
Product Type Chemical
Properties
Formula

C141H203N41O38 . C2HF3O2

MW 3080.4 . 114.0
Sequence

H-Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-amide

CAS 312306-89-1
Source/Host Chemicals Synthetic.
Purity Chemicals ≥98% (HPLC)
Appearance Lyophilized powder.
Solubility Soluble in water.
Crossreactivity Human
Identity Determined by MS.
InChi Key SJLXOEXLOIEAIN-PJDLJQKUSA-N
Smiles C[C@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC3=CC=CC=C3)=O)CCC(N)=O)=O)CO)=O)=O)CC4=CC=CC=C4)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(N)=O)CC(N)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CC6=CC=CC=C6)=O)CC(C)C)=O)CC7=CC=CC=C7)=O)CC8=CC=C(O)C=C8)=O)=O)CCCNC(N)=N)=O)CO)=O)CCC(N)=O)=O)CO)=O.FC(F)(C(O)=O)F
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Active human form of NMU.
  • Binds to two high affinity G-protein coupled receptors, NMUR1 and NMUR2, with NMUR1 predominantly expressed in the peripheral tissues and NMUR2 mainly expressed in the CNS.
  • The activation of NMURs leads to intracellular signal transduction via calcium mobilization, phosphoinositide (or PI) signaling and the inhibition of cAMP production and therefore has diverse functions including contraction of smooth muscle, vasoconstriction, nociception, appetite and bone remodeling.
  • Implicated in a number of physiological processes including the regulation of feeding, energy homeostasis and glycemic control and therefore used to target obesity and diabetes.
  • Activator of innate lymphoid cells 2 (ILC2) during inflammation, as shown in studies in mice [6-8].
Product References
  1. Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system: J.D. Mitchell, et al.; Cardiovasc. Res. 81, 353 (2009)
  2. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S: J.D. Mitchell, et al.; Br. J. Pharmacol. 158, 87 (2009) (Review)
  3. Peptides and their potential role in the treatment of diabetes and obesity: H.C. Greenwood, et al.; Rev. Diabet. Stud. 8, 355 (2011) (Review)
  4. Suppression of insulin production and secretion by a decretin hormone: R. W. Alfa, et al.; Cell Metab. 21, 323 (2015)
  5. Neuromedin U: a multifunctional neuropeptide with pleiotropic roles: V.G. Martinez & L. O'Driscoll; Clin. Chem. 61, 471 (2015) (Review)
  6. The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation: C.S.N. Klose, et al.; Nature 549, 282 (2017)
  7. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation: A. Wallrapp, et al.; Nature 549, 351 (2017)
  8. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U: V. Cardoso, et al.; Nature 549, 277 (2017)
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