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AdipoGen Life Sciences
anti-AIM2 (human), mAb (3B10)
330
CHF
CHF 330.00
In stock
AG-20B-0040-C100100 µgCHF 330.00
| Product Details | |
|---|---|
| Synonyms | Interferon-inducible Protein AIM2; Absent in Melanoma 2 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 3B10 |
| Isotype | Mouse IgG1 |
| Source/Host | Purified from concentrated hybridoma tissue culture supernatant. |
| Immunogen/Antigen | Human AIM2 (aa 1-186). |
| Application |
ICC: (1:200) |
| Crossreactivity | Human |
| Specificity |
Recognizes human AIM2. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein G-affinity purified. |
| Endotoxin Content | |
| Concentration | 1 mg/ml |
| Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
UniProt link O14862: AIM2 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16 [8], MNDA [9], AIM2 [1] and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1β.
Product References
- Expression of IFI 16 in epithelial cells and lymphoid tissues: W. Wei, et al.; Histochem. Cell Biol. 119, 45 (2003)
- Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2: K.S. Cresswell, et al.; BBRC 326, 417 (2005)
- AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA: T. Fernandes-Alnemri, et al.; Nature 458, 509 (2009)
- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC: V. Hornung, et al.; Nature 458, 514 (2009)
- A novel flow cytometric method to assess inflammasome formation: D.P. Sester, et al.; J. Immunol. 194, 455 (2015)
- Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection: C. Sun, et al.; J. Immunol. 194, 1819 (2015)
- Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication: Y. Maruzuru, et al.; Cell Host Microbe. 23, 254 (2018)
- PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells: D. Massa, et al.; J. Biol. Chem. 295, 4438 (2020)
- Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7: L. Gu, et al.; Nature Comm. 13, 14 (2022)
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