Streptozotocin

CHF 35.00
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AG-CN2-0046-M05050 mgCHF 35.00
AG-CN2-0046-M250250 mgCHF 70.00
AG-CN2-0046-G0011 gCHF 150.00
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Product Details
Synonyms 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; Streptozocin; STZ; NSC 85998; Antibiotic U9889; Zanosar
Product Type Chemical
Properties
Formula C8H15N3O7
MW 265.2
Merck Index 14: 8832
CAS 18883-66-4
RTECS LZ5775000
Purity Chemicals ≥98% (HPLC)
≥75% (α anomer)
Appearance Off-white to pale yellow powder.
Solubility Soluble in water or ethanol.
Identity Determined by UV and IR.
Other Product Data Note: Once the compound is in solution it spontaneously releases NO gas at room temperature. We recommend to prepare fresh solutions immediately before use.

LIT: Anomer-equilibrated streptozotocin solution for the induction of experimental diabetes in mice (Mus musculus): A.S. de la Garza-Rodea, et al.; J. Am. Assoc. Lab. Anim. Sci. 49, 40 (2010)
InChi Key ZSJLQEPLLKMAKR-GKHCUFPYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antibiotic [1].
  • Diabetogenic. Diabetes inducer. Induces diabetes mellitus in animal models through its toxic effects on pancreatic β-cells [2, 5, 13, 14].
  • Mutagenic [3, 10].
  • Potent alkylating agent. Potent DNA methylating agent [4, 10].
  • Nitric oxide (NO) donor. Vasorelaxant [6].
  • Cytotoxic to cells that express GLUT2 glucose transporter [7].
  • O-GlcNAc-selective N-acetyl-β-D-glucosaminidase (O-GlcNAcase) inhibitor [8].
  • Genotoxic. Induces DNA damage. Produces DNA strand breaks [9, 10]. Cell death inducer [15].
  • Antineoplastic. Anti-cancer agent used in chemotherapy [10, 11].
  • Induces cell cylce arrest at G2 [12].
Product References
  1. Streptozotocin, a new antibacterial antibiotic: J.J. Vavra, et al.; Antibiot. Ann. 7, 230 (1959)
  2. Studies on the diabetogenic action of Streptozotocin: N. Raketien, et al.; Cancer Chemother. Rep. 29, 91 (1963)
  3. Mutagenic activity of Streptozotocin: S.M. Kolbye & M.S. Legator; Mutat. Res. 6, 387 (1968)
  4. Alkylation of DNA in rat tissues following administration of streptozotocin: R.A. Bennett & A.E. Pegg; Cancer Res. 41, 2786 (1981)
  5. Streptozotocin interactions with pancreatic beta cells and the induction of insulin-dependent diabetes: G.L. Wilson & E.H. Leiter; Curr. Top. Microbiol. Immunol. 156, 27 (1990) (Review)
  6. Nitric oxide generation from streptozotocin: N.S. Kwon, et al.; FASEB J. 8, 529 (1994)
  7. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells: W.J. Schnedl, et al.; Diabetes 43, 1326 (1994)
  8. Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death: K. Liu, et al.; PNAS 97, 2820 (2000)
  9. Chromosomal response of human lymphocytes to Streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 503, 63 (2002)
  10. Genotoxicity of streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 512, 121 (2002) (Review)
  11. Clastogenic effects of streptozotocin on human colon cancer cell lines with gene amplification: A.D. Bolzan & M.S. Bianchi;  J. Environ. Pathol. Toxicol. Oncol. 22, 281 (2003)
  12. Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo: A.P. Johnston, et al.; Am. J. Physiol. Cell Physiol. 292, C1033 (2007)
  13. The mechanisms of alloxan- and streptozotocin-induced diabetes: S. Lenzen; Diabetologia 51, 216 (2008)
  14. Mechanisms of toxic effect of streptozotocin on β-cells in the islets of langerhans: V.B. Pisarev, et al.; Bull. Exp. Biol. Med. 148, 937 (2009)
  15. The role of programmed cell death in streptozotocin-induced early diabetic nephropathy: W.H. Wu, et al.; J. Endocrinol. Invest. 34, e296 (2011)
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