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AdipoGen Life Sciences
Rugulosin
55
CHF
CHF 55.00
In stock
AG-CN2-0124-C250250 µgCHF 55.00
AG-CN2-0124-M0011 mgCHF 170.00
| Product Details | |
|---|---|
| Synonyms | (+)-Rugulosin; NSC 160880; NSC 249990; Radicalisin |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H22O10 |
| MW | 542.5 |
| CAS | 23537-16-8 |
| RTECS | VM1610000 |
| Source/Host Chemicals | Isolated from Penicillium sp. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO, ethanol or methanol. |
| InChi Key | QFDPVUTXKUGISP-UHFFFAOYSA-N |
| Smiles | CC1=CC2=C(C(O)=C1)C(=O)C1=C(O)[C@H]3C(O)C4C5C(O)[C@H](C(O)=C6C(=O)C7=C(O)C=C(C)C=C7C(=O)C356)C14C2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [1].
- Antibacteriophage. Antiviral [2].
- Mycotoxin [3].
- DNA replication, transcription and repair inhibitor [4].
- Antibacterial [5].
- RNA polymerase and ribonuclease H inhibitor [6].
- Insecticidal. Cytotoxic [7].
- HIV-1 integrase inhibitor [8].
- Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity [9].
- Potential Hsp90 inhibitor through interacting with N-Hsp90 [10].
Product References
- Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom: J. Breen, et al.; Biochem. J. 60, 618 (1955)
- Inhibition of phage growth by an antibiotic rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect: S. Nakamura, et al.; Jpn. J. Microbiol. 15, 113 (1971)
- Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom: Y. Ueno, et al.; Jpn. J. Exp. Med. 41, 177 (1971)
- Specific and non-specific interactions of two carcinogenic mycotoxins, luteoskyrin and rugulosin with nucleic acids: J.C. Bouhet, et al.; Ann. Nutr. Aliment. 31, 811 (1977)
- Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum: A.A. Stark, et al.; J. Environ. Pathol. Toxicol. 2, 313 (1978)
- Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H: F. Tashiro, et al.; Appl. Environ. Microbiol. 38, 191 (1979)
- Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): possible agents for biological control: P. Watts, et al.; Mycol. Res. 107, 581 (2003)
- Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003)
- New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2: H. Yamazaki, et al.; Org. Lett. 12, 1572 (2010)
- Inhibition and binding of Rugulosin with N-Hsp90: J.-J.Chen, et al.; Gaodeng Xuexiao Huaxue Xuebao 32, 88 (2011)
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