Rugulosin

CHF 65.00
In stock
AG-CN2-0124-C250250 µgCHF 65.00
AG-CN2-0124-M0011 mgCHF 190.00
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Product Details
Synonyms (+)-Rugulosin; NSC 160880; NSC 249990; Radicalisin
Product Type Chemical
Properties
Formula

C30H22O10

MW 542.5
CAS 23537-16-8
RTECS VM1610000
Source/Host Chemicals Isolated from Penicillium sp.
Purity Chemicals ≥95% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO, ethanol or methanol.
InChi Key QFDPVUTXKUGISP-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antibiotic [1].
  • Antibacteriophage. Antiviral [2].
  • Mycotoxin [3].
  • DNA replication, transcription and repair inhibitor [4].
  • Antibacterial [5].
  • RNA polymerase and ribonuclease H inhibitor [6].
  • Insecticidal. Cytotoxic [7].
  • HIV-1 integrase inhibitor [8].
  • Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity [9].
  • Potential Hsp90 inhibitor through interacting with N-Hsp90 [10].
Product References
  1. Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom: J. Breen, et al.; Biochem. J. 60, 618 (1955)
  2. Inhibition of phage growth by an antibiotic rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect: S. Nakamura, et al.; Jpn. J. Microbiol. 15, 113 (1971)
  3. Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom: Y. Ueno, et al.; Jpn. J. Exp. Med. 41, 177 (1971)
  4. Specific and non-specific interactions of two carcinogenic mycotoxins, luteoskyrin and rugulosin with nucleic acids: J.C. Bouhet, et al.; Ann. Nutr. Aliment. 31, 811 (1977)
  5. Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum: A.A. Stark, et al.; J. Environ. Pathol. Toxicol. 2, 313 (1978)
  6. Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H: F. Tashiro, et al.; Appl. Environ. Microbiol. 38, 191 (1979)
  7. Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): possible agents for biological control: P. Watts, et al.; Mycol. Res. 107, 581 (2003)
  8. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003)
  9. New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2: H. Yamazaki, et al.; Org. Lett. 12, 1572 (2010)
  10. Inhibition and binding of Rugulosin with N-Hsp90: J.-J.Chen, et al.; Gaodeng Xuexiao Huaxue Xuebao 32, 88 (2011)
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