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AdipoGen Life Sciences
Skyrin
200
CHF
CHF 200.00
In stock
AG-CN2-0001-M0011 mgCHF 200.00
| Product Details | |
|---|---|
| Synonyms | Rhodophyscin; Endothianin; 4,4′-Biemodin |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H18O10 |
| MW | 538.5 |
| CAS | 602-06-2 |
| Source/Host Chemicals | Isolated from fungus Talaromyces sp. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Orange to dark red solid. |
| Solubility | Soluble in 100% ethanol or DMSO. |
| InChi Key | MQSXZQXHIJMNAF-UHFFFAOYSA-N |
| Smiles | CC1=CC2=C(C(O)=C1)C(=O)C1=C(C2=O)C(=C(O)C=C1O)C1=C(O)C=C(O)C2=C1C(=O)C1=C(C(O)=CC(C)=C1)C2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Non-peptidic anti-diabetic agent [1].
- Receptor-selective glucagon antagonist [1].
- Free radical species (·OH, R·) and singlet oxygen (1O2) scavenger [2].
- Mycotoxin [3, 4].
- Cytotoxic [3, 4].
- Antioxidant [2].
- Inhibitor of botulinum neurotoxin serotype A (BoNTA) [5].
- Anti-MRSA compound [6].
- Antibiotic [7].
Product References
- Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes: J.C. Parker, et al.; Diabetes 49, 2079 (2000)
- Antioxidant and scavenging activity of skyrin on free radical and some reactive oxygen species: F. Vargas, et al.; Avances en Quimica 3, 7 (2008)
- The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH-154 isolated from Kandelia candel (L.) Druce: F. Liu, et al.; Planta Med. 76, 185 (2010)
- A comparative study on cytotoxicities and biochemical properties of anthraquinone mycotoxins emodin and skyrin from Penicillium islandicum Sopp: K. Kawai, et al.; Toxicol. Lett. 20, 155 (1984)
- Fungal bis-naphthopyrones as inhibitors of Botulinum neurotoxin serotype A: J. H. Cardellina II, e. Al.; ACS Med. Chem. Lett. 3, 387 (2012)
- Atropisomeric dihydroanthracenones as inhibitors of multiresistant Straphylococcus aureus: R. Bara, et al.; J. Med. Chem. 56, 3257 (2013)
- Antibiotically active metabolites from Talaromyces wortmannii, an endophyte of Aloe vera: R. Bara, et al.; J. Antibiot. 66, 491 (2013)
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