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AdipoGen Life Sciences
Apcin
100
CHF
CHF 100.00
In stock
AG-CR1-3603-M0055 mgCHF 100.00
AG-CR1-3603-M02525 mgCHF 350.00
| Product Details | |
|---|---|
| Synonyms | Anaphase Promoting Complex Inhibitor |
| Product Type | Chemical |
| Properties | |
| Formula |
C13H14Cl3N7O4 |
| MW | 438.7 |
| CAS | 300815-04-7 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (20mM). |
| Identity | Determined by 1H-NMR. |
| InChi Key | ZEXHXVOGJFGTRX-UHFFFAOYSA-N |
| Smiles | CC1=NC=C(N1CCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl)[N+]([O-])=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis.
- Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20.
- Distinct mechanism of action than proTAME.
- Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.
Product References
- Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C: K.L. Sackton, et al.; Nature 514, 646 (2014)