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AdipoGen Life Sciences
Eupatilin
70
CHF
CHF 70.00
In stock
AG-CN2-0432-M0055 mgCHF 70.00
AG-CN2-0432-M02525 mgCHF 280.00
| Product Details | |
|---|---|
| Synonyms | 5,7-Dihydroxy-3',4',6-trimethoxyflavone; NSC 122413 |
| Product Type | Chemical |
| Properties | |
| Formula |
C18H16O7 |
| MW | 344.3 |
| CAS | 22368-21-4 |
| Source/Host Chemicals | Isolated from Artemisia sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Pale yellow powder. |
| Solubility | Soluble in DMSO, hot methanol or mixture of methanol and chloroform. |
| Identity | Determined by 1H-NMR. |
| InChi Key | DRRWBCNQOKKKOL-UHFFFAOYSA-N |
| Smiles | COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)O)OC)O)OC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective inhibitor of 5-lipoxygenase.
- Anti-proliferative and anticancer compound.
- Apoptosis and cell cycle arrest inducer.
- Inhibits ERK1/2, JNK, and NF-κB activation and expression of Raf-1 and Ras.
- PI3K Class I, MKK3/6 and MKK4 inhibitor.
- Inhibits angiogenesis by blocking STAT3 and VEGF expression.
- Anti-inflammatory and immunosuppressive agent.
- Antioxidant.
- Antidiabetic. Enhances hepatic and plasma glucose metabolism and increases insulin secretion in type 2 diabetic mice.
- Selective PPARα agonist.
- Neuroprotective.
Product References
- Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai: Y. Koshihara, et al.; FEBS Lett. 158, 41 (1983)
- Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells: H.J. Seo & Y.J. Surh; Mutat. Res. 496, 191-8 (2001)
- Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells: D.H. Kim, et al.; Biochem. Pharmacol. 68, 1081 (2004)
- Eupatilin blocks mediator release via tyrosine kinase inhibition in activated guinea pig lung mast cells: J.Y Kim, et al.; J. Toxicol. Environ. Health A. 68, 2063 (2005)
- Eupatilin has an antiapoptotic action on hepatocytes, in contrast to apoptotic actions on other cells: T. Mine; J. Gastroenterol. 41, 818 (2006)
- Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress: E.J. Choi, et al.; Pharm. Res. 25, 1355 (2008)
- Eupatilin inhibits H(2)O(2)-induced apoptotic cell death through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB: S. Lee, et al.; Food Chem. Toxicol. 46, 2865 (2008)
- Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice: Y.J. Kang, et al.; Diabetes Res. Clin. Pract. 82, 25 (2008)
- Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells: E.J. Choi, et al.; Differentiation 77, 412 (2009)
- Eupatilin inhibits T-cell activation by modulation of intracellular calcium flux and NF-kappaB and NF-AT activity: Y.D. Kim, et al.; J. Cell Biochem. 108, 225 (2009)
- Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression: J.H. Cheong, et al.; J. Gastric Cancer 11, 16 (2011)
- The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice: M. Cai, et al.; Eur. J. Pharmacol. 689, 104 (2012)
- Eupatilin, a major flavonoid of Artemisia, attenuates aortic smooth muscle cell proliferation and migration by inhibiting PI3K, MKK3/6, and MKK4 activities: J.E. Son, et al.; Planta Med. 79, 1009 (2013)
- Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement: J.-Y. Kim, et al.; Bone Rep. 3, 83 (2015)
- Identification of eupatilin from Artemisia argyi as a selective PPARα agonist using affinity selection ultrafiltration LC-MS: Y. Choi, et al.; Molecules 20, 13753 (2015)
- Eupatilin suppresses the allergic inflammatory response in vitro and in vivo: E-H. Song, et al.; Phytomed. 42, 1 (2018)
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