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AdipoGen Life Sciences
Ciglitazone
45
CHF
CHF 45.00
In stock
AG-CR1-0033-M0011 mgCHF 45.00
AG-CR1-0033-M0055 mgCHF 110.00
AG-CR1-0033-M02525 mgCHF 440.00
| Product Details | |
|---|---|
| Synonyms | (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione; U-63287 |
| Product Type | Chemical |
| Properties | |
| Formula |
C18H23NO3S |
| MW | 333.5 |
| CAS | 74772-77-3 |
| RTECS | XJ5813700 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO or 100% ethanol. |
| Identity | Determined by 1H-NMR. |
| Other Product Data |
Stock solutions are stable for up to 3 months when stored at -20°C. |
| InChi Key | YZFWTZACSRHJQD-UHFFFAOYSA-N |
| Smiles | CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective PPARγ agonist (EC50=3 µM) [1].
- Hypoglycemic agent [2, 3].
- Angiogenesis inhibitor [4].
- Anti-inflammatory [5].
- Apoptosis inducer [6].
Product References
- The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996)
- Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent: T. Fujita, et al.; Diabetes 32, 804 (1983)
- [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994)
- Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999)
- The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice: M.E. Stegenga, et al.; Crit. Care Med. 37, 614 (2009)
- Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock: R.S. Chima, et al.; Int. J. Clin. Exp. Med. 3, 1 (2010)
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