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AdipoGen Life Sciences
Rasfonin
230
CHF
CHF 230.00
In stock
AG-CN2-0173-C500500 µgCHF 230.00
| Product Details | |
|---|---|
| Synonyms | (-)-Rasfonin; TT-1 |
| Product Type | Chemical |
| Properties | |
| Formula |
C25H38O6 |
| MW | 434.6 |
| CAS | 303156-68-5 |
| Source/Host Chemicals | Isolated from Trichurus sp. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Tan to brown viscous liquid (oily). |
| Solubility | Soluble in ethanol, methanol or DMSO (all 1mg/ml). |
| InChi Key | OHRGHFXATDKGOV-MDKHPKFKSA-N |
| Smiles | O=C1O[C@@]([C@H](C[C@@H](C)C/C(C)=C/C)C)([H])C(OC(/C=C/C(C)=C/[C@@H](CO)CCO)=O)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective apoptosis inducer in ras-dependent cells.
- Autophagy (Akt-dependent), apoptosis and necroptosis inducer in renal cancer cell lines.
- Induces death of ras-mutated pancreatic tumor (Panc-1) cells in vitro and in vivo.
- Robust inhibitor of pancreatic cancers with the K-ras mutation. Reduced Sos1 expression and depressed Ras-MAPK activity.
Product References
- Rasfonin, a New Apoptosis Inducer in ras-dependent Cells from Talaromyces sp.: T. Tomikawa, et al.; J. Antibiot. 53, 848 (2000)
- Total synthesis of TT-1 (rasfonin), an α-pyrone-containing natural product from a fungus Trichurus terrophilus: K. Akiyama, et al.; Tetrahedron 61, 1827 (2005)
- Toward the Development of a General Chiral Auxiliary. Enantioselective Alkylation and a New Catalytic Asymmetric Addition of Silyloxyfurans: Application to a Total Synthesis of (-)-Rasfonin: R.K. Boeckman, et al.; JACS 128, 11032 (2006)
- Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice: Z. Xiao, et al.; Cell Death Dis. 22, e1241 (2014)
- Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells: Q. Lu, et al.; Cell Death Dis. 6, e2005 (2015)
- Rasfonin promotes autophagy and apoptosis via upregulation of reactive oxygen species (ROS)/JNK pathway: W. Wang, et al.; Mycology 7, 64 (2016)
- Fungal secondary metabolites rasfonin induces autophagy, apoptosis and necroptosis in renal cancer cell line: H. Sun, et al.; Mycology 7, 81 (2016)
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