AdipoGen Life Sciences

DLL4 (human):Fc (human) (rec.) (highly active mutant)

CHF 350.00
In stock
AG-40B-0176-C01010 µgCHF 350.00
AG-40B-0176-C100100 µgCHF 1'080.00
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Product Details
Synonyms Delta-like Protein 4; Delta4
Product Type Protein
Source/Host HEK 293 cells

Extracellular domain of human DLL4 (aa 27-529 plus mutations) are fused at the C-terminus to the Fc portion of human IgG1.

Crossreactivity Human

Interacts with human and mouse Notch1 with >20 fold increase in affinity relative to WT DLL4 (as confirmed by ELISA).

MW ~100kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test).
Concentration After reconstitution:
for 10µg size: 0.1mg/ml
for 100µg size: 1 mg/ml
Reconstitution Reconstitute with 100µl sterile endotoxin-free water.
Formulation Lyophilized. Contains PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

UniProt link Q9NR61: DLL4 (human) [Precursor]

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.

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