35 CHF CHF 35.00
AG-CN2-0531-M01010 mgCHF 35.00
AG-CN2-0531-M05050 mgCHF 60.00
AG-CN2-0531-M250250 mgCHF 180.00
|Synonyms||3,4-DMC; NSC643172; 3-(3,4-Dimethoxyphenyl)-1-phenylprop-2-en-1-one|
|Purity Chemicals||≥98% (HPLC)|
|Appearance||White to yellow crystalline powder.|
|Solubility||Soluble in DMSO.|
|Identity||Determined by 1H-NMR|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Keep cool and dry.|
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Caloric restriction mimetic (CRM). Caloric restriction mimetics (CRMs) are natural or synthetic compounds that mimic the health-promoting and longevity-extending effects of caloric restriction. CRMs provoke the deacetylation of cellular proteins coupled to an increase in autophagic flux in the absence of toxicity.
- Induces the deacetylation of cytoplasmic proteins and stimulates autophagic flux, requiring transcription factor EB (TFEB)- and E3 (TFE3)-dependent gene transcription and mRNA translation to trigger autophagy.
- Stimulates the translocation of TFEB and TFE3 into nuclei both in vitro and in vivo, in hepatocytes and cardiomyocytes. Consequently induces autophagy in vitro and in vivo, mediates autophagy-dependent cardioprotective effects and improves the efficacy of anticancer chemotherapy in vivo.
- So far this chalcone polyphenol has been used as an intermediate for synthesis of biochemical substances and was described to have weak antioxidant and antimicrobial activity.
- Antioxidant properties of phenyl styryl ketones: D.V. Rajakumar & M.N. Rao; Free Radic. Res. 22, 309 (1995)
- In vitro antifungal evaluation and structure-activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall: S.N. Lopez, et al.; Bioorg. Med. Chem. 9, 1999 (2001)
- Quinone reductase 2 substrate specificity and inhibition pharmacology: J.A. Boutin, et al.; Chem. Biol. Interact. 151, 213 (2005)
- 3,4-Dimethoxychalcone: V. Shettigar, et al.; Acta Cryst. E62, o4646 (2006)
- 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB: G. Chen, et al.; EMBO Mol. Med. e10469, (2019)