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AdipoGen Life Sciences
3,4-Dimethoxychalcone
35
CHF
CHF 35.00
In stock
AG-CN2-0531-M01010 mgCHF 35.00
AG-CN2-0531-M05050 mgCHF 60.00
AG-CN2-0531-M250250 mgCHF 180.00
| Product Details | |
|---|---|
| Synonyms | 3,4-DMC; NSC643172; 3-(3,4-Dimethoxyphenyl)-1-phenylprop-2-en-1-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H16O3 |
| MW | 268.3 |
| CAS | 5416-71-7 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to yellow crystalline powder. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR |
| InChi Key | LSHZPTCZLWATBZ-CSKARUKUSA-N |
| Smiles | COC1=CC=C(C=C1OC)/C=C/C(C2=CC=CC=C2)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Caloric restriction mimetic (CRM). Caloric restriction mimetics (CRMs) are natural or synthetic compounds that mimic the health-promoting and longevity-extending effects of caloric restriction. CRMs provoke the deacetylation of cellular proteins coupled to an increase in autophagic flux in the absence of toxicity.
- Induces the deacetylation of cytoplasmic proteins and stimulates autophagic flux, requiring transcription factor EB (TFEB)- and E3 (TFE3)-dependent gene transcription and mRNA translation to trigger autophagy.
- Stimulates the translocation of TFEB and TFE3 into nuclei both in vitro and in vivo, in hepatocytes and cardiomyocytes. Consequently induces autophagy in vitro and in vivo, mediates autophagy-dependent cardioprotective effects and improves the efficacy of anticancer chemotherapy in vivo.
- So far this chalcone polyphenol has been used as an intermediate for synthesis of biochemical substances and was described to have weak antioxidant and antimicrobial activity.
Product References
- Antioxidant properties of phenyl styryl ketones: D.V. Rajakumar & M.N. Rao; Free Radic. Res. 22, 309 (1995)
- In vitro antifungal evaluation and structure-activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall: S.N. Lopez, et al.; Bioorg. Med. Chem. 9, 1999 (2001)
- Quinone reductase 2 substrate specificity and inhibition pharmacology: J.A. Boutin, et al.; Chem. Biol. Interact. 151, 213 (2005)
- 3,4-Dimethoxychalcone: V. Shettigar, et al.; Acta Cryst. E62, o4646 (2006)
- 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB: G. Chen, et al.; EMBO Mol. Med. e10469, (2019)
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