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AdipoGen Life Sciences
Paprotrain
125
CHF
CHF 125.00
In stock
AG-CR1-3504-M0011 mgCHF 125.00
| Product Details | |
|---|---|
| Synonyms | (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H11N3 |
| MW | 245.3 |
| CAS | 57046-73-8 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO (at least 5 mg/ml). |
| InChi Key | YMYYQRZCCKBFBE-MDWZMJQESA-N |
| Smiles | [H]\C(=C(\C#N)C1=CNC2=C1C=CC=C2)C1=CN=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable and reversible kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor [1].
- Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation [1].
- Moderate DYRK1A inhibitor (IC50= 5.5 μM). Lead compound [3].
Product References
- Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin-Specific MKLP-2 Inhibitor: S. Tcherniuk, et al.; Angew. Chem. (Int'l Ed.) 49, 8228 (2010)
- New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations: C. Labrière, et al.; Bioorg. Med. Chem. 24, 721 (2016)
- Further investigation of paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors: C. Labrière, et al.; Eur. J. Med. Chem. 124, 920 (2016)
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