AdipoGen Life Sciences

Paprotrain

Name: Paprotrain
Brand: AdipoGen Life Sciences
SKU: AG-CR1-3504
Price: 120.00 CHF
Availability: InStock

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AG-CR1-3504-M0011 mgCHF 120.00

Specifications / Handling

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Product Details
Synonyms	(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
Product Type	Chemical
Properties
Formula	C₁₆H₁₁N₃
MW	245.3
CAS	57046-73-8
Purity Chemicals	≥98% (NMR)
Appearance	Yellow solid.
Solubility	Soluble in DMSO (at least 5 mg/ml).
InChi Key	YMYYQRZCCKBFBE-MDWZMJQESA-N
Smiles	[H]\C(=C(\C#N)C1=CNC2=C1C=CC=C2)C1=CN=CC=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Cell permeable and reversible kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor [1].
Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation [1].
Moderate DYRK1A inhibitor (IC₅₀= 5.5 μM). Lead compound [3].

Product-specific References

Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin-Specific MKLP-2 Inhibitor: S. Tcherniuk, et al.; Angew. Chem. (Int'l Ed.) 49, 8228 (2010)
New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations: C. Labrière, et al.; Bioorg. Med. Chem. 24, 721 (2016)
Further investigation of paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors: C. Labrière, et al.; Eur. J. Med. Chem. 124, 920 (2016)

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