AdipoGen Life Sciences


CHF 90.00
In stock
AG-CR1-0160-M0055 mgCHF 90.00
AG-CR1-0160-M02525 mgCHF 270.00
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Product Details
Synonyms 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
Product Type Chemical


MW 210.2
CAS 1346526-26-8
Purity Chemicals ≥98% (HPLC)
Appearance Off-white to tan solid.
Solubility Soluble in DMSO (2mg/ml), ethanol or methanol. Insoluble in water.
Identity Determined by 1H-NMR.
Smiles OC(C=C1)=CC=C1C2=CC3=CC=CN=C3N2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Specific competitive RIPK1 inhibitor in vitro (IC50=1.03µM). Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases.
  • Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2µM). Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine.
  • Protects mice from concanavalin A-induced hepatitis in vivo.
Product References
  1. Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis: F. Le Cann, et al.; FEBS J. 284, 3050 (2017)
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