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AdipoGen Life Sciences
Necrostatin-5
55
CHF
CHF 55.00
In stock
AG-CR1-0049-M0055 mgCHF 55.00
AG-CR1-0049-M02525 mgCHF 220.00
| Product Details | |
|---|---|
| Synonyms | Nec-5; 3-p-Methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide |
| Product Type | Chemical |
| Properties | |
| Formula |
C19H17N3O2S2 |
| MW | 383.5 |
| CAS | 337349-54-9 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (> 10 mg/ml). |
| InChi Key | VGONMECBFMCKBS-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)N1C(=O)C2=C(SC3=C2CCCC3)N=C1SCC#N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Necroptosis inhibitor [1].
- Indirect RIP1 kinase inhibitor [2].
- Cardioprotective
Product References
- Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5: K. Wang, et al.; Bioorg. Med. Chem. Lett. 17, 1455 (2007)
- Idenfication of RIP1 kinase as a specific cellular target of necrostatins: A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008)
- Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion: Y.V. Dimitriev, et al.; Bull. Exp. Biol. Med. 155, 245 (2013)