Lac-Phe . acetate

CHF 140.00
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AG-CR1-3545-M01010 mgCHF 140.00
AG-CR1-3545-M05050 mgCHF 560.00
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Product Details
Synonyms N-Lactoyl-L-phenylalanine
Product Type Chemical
Properties
Formula

C12H15NO4 . C2H3O2

MW 237.3 . 59.0
CAS 183241-73-8
Purity Chemicals ≥95% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in water.
InChi Key TXEKHKMVDUMVBF-GNAZCLTHSA-M
Smiles C[C@H](O)C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O.CC([O-2])=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF
  • Lac-Phe is an exercise-inducible metabolite, also called exerkine, that suppresses feeding and obesity. Lac-Phe is increased heavily with exercise in mammals and acts to reduce food intake and potentially decrease overall body weight and fat mass.
  • In diet-induced obese mice, pharmacological administration of Lac-Phe led to decreased food intake, adiposity and body weight, as well as improved glucose homeostasis, while movement and energy expenditure were not affected.
  • The biosynthesis of Lac-Phe from lactate and phenylalanine occurs in CNDP2+ cells, including macrophages, monocytes and other immune and epithelial cells.
Product References
  1. An exercise-inducible metabolite that suppresses feeding and obesity: V.L. Li, et al.; Nature 606, 785 (2022)
  2. Exerkines in health, resilience and disease: L.S. Chow, et al.; Nature Review Endocrinol. 18, 273 (2022)
  3. An exercise-induced metabolite alters feeding: C. Greenhill: Nature Review Endocrinol. 18, 521 (2022)
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