Lac-Phe . acetate
140 CHF CHF 140.00
AG-CR1-3545-M01010 mgCHF 140.00
AG-CR1-3545-M05050 mgCHF 560.00
C12H15NO4 . C2H3O2
|MW||237.3 . 59.0|
|Purity Chemicals||≥95% (HPLC)|
|Appearance||White to off-white powder.|
|Solubility||Soluble in water.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Lac-Phe is an exercise-inducible metabolite, also called exerkine, that suppresses feeding and obesity. Lac-Phe is increased heavily with exercise in mammals and acts to reduce food intake and potentially decrease overall body weight and fat mass.
- In diet-induced obese mice, pharmacological administration of Lac-Phe led to decreased food intake, adiposity and body weight, as well as improved glucose homeostasis, while movement and energy expenditure were not affected.
- The biosynthesis of Lac-Phe from lactate and phenylalanine occurs in CNDP2+ cells, including macrophages, monocytes and other immune and epithelial cells.
- An exercise-inducible metabolite that suppresses feeding and obesity: V.L. Li, et al.; Nature 606, 785 (2022)
- Exerkines in health, resilience and disease: L.S. Chow, et al.; Nature Review Endocrinol. 18, 273 (2022)
- An exercise-induced metabolite alters feeding: C. Greenhill: Nature Review Endocrinol. 18, 521 (2022)