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AdipoGen Life Sciences
Lac-Phe . acetate
140
CHF
CHF 140.00
In stock
AG-CR1-3545-M01010 mgCHF 140.00
AG-CR1-3545-M05050 mgCHF 560.00
| Product Details | |
|---|---|
| Synonyms | N-Lactoyl-L-phenylalanine |
| Product Type | Chemical |
| Properties | |
| Formula |
C12H15NO4 . C2H3O2 |
| MW | 237.3 . 59.0 |
| CAS | 183241-73-8 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water. |
| InChi Key | TXEKHKMVDUMVBF-GNAZCLTHSA-M |
| Smiles | C[C@H](O)C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O.CC([O-2])=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Lac-Phe is an exercise-inducible metabolite, also called exerkine, that suppresses feeding and obesity. Lac-Phe is increased heavily with exercise in mammals and acts to reduce food intake and potentially decrease overall body weight and fat mass.
- In diet-induced obese mice, pharmacological administration of Lac-Phe led to decreased food intake, adiposity and body weight, as well as improved glucose homeostasis, while movement and energy expenditure were not affected.
- The biosynthesis of Lac-Phe from lactate and phenylalanine occurs in CNDP2+ cells, including macrophages, monocytes and other immune and epithelial cells.
Product References
- An exercise-inducible metabolite that suppresses feeding and obesity: V.L. Li, et al.; Nature 606, 785 (2022)
- Exerkines in health, resilience and disease: L.S. Chow, et al.; Nature Review Endocrinol. 18, 273 (2022)
- An exercise-induced metabolite alters feeding: C. Greenhill: Nature Review Endocrinol. 18, 521 (2022)