80 CHF CHF 80.00
AG-CR1-0159-M0011 mgCHF 80.00
AG-CR1-0159-M0055 mgCHF 195.00
AG-CR1-0159-M02525 mgCHF 490.00
|Purity Chemicals||≥98% (HPLC)|
|Appearance||White to off-white solid.|
|Solubility||Soluble in DMSO, ethanol, methanol or DCM. Insoluble in water.|
|Identity||Determined by 1H-NMR.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Keep cool and dry.|
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90β heterocomplexes, consequently blocking its function and inhibiting cancer cell motility.
- Does not bind to Cdc37 or HSP90β alone.
- Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer.
- Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
- Precision therapeutic targeting of human cancer cell motility: L. Xu, et al.; Nat. Commun. 9, 2454 (2018)