KBU2046

More Information
Product Details
Synonyms	3-(4-Fluorophenyl)-chroman-4-one
Product Type	Chemical
Properties
Formula	C₁₅H₁₁FO₂
MW	242.2
CAS	1143863-69-7
Purity Chemicals	≥98% (HPLC)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO, ethanol, methanol or DCM. Insoluble in water.
Identity	Determined by ¹H-NMR.
InChi Key	XKAFGKFIJBGYAP-UHFFFAOYSA-N
Smiles	O=C1C(C2=CC=C(F)C=C2)COC3=CC=CC=C31
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90β heterocomplexes, consequently blocking its function and inhibiting cancer cell motility.
Does not bind to Cdc37 or HSP90β alone.
Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer.
Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.

Product References

Precision therapeutic targeting of human cancer cell motility: L. Xu, et al.; Nat. Commun. 9, 2454 (2018)

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