KBU2046

CHF 80.00
In stock
AG-CR1-0159-M0011 mgCHF 80.00
AG-CR1-0159-M0055 mgCHF 195.00
AG-CR1-0159-M02525 mgCHF 490.00
NEW
More Information
Product Details
Synonyms 3-(4-Fluorophenyl)-chroman-4-one
Product Type Chemical
Properties
Formula

C15H11FO2

MW 242.2
CAS 1143863-69-7
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO, ethanol, methanol or DCM. Insoluble in water.
Identity Determined by 1H-NMR.
InChi Key XKAFGKFIJBGYAP-UHFFFAOYSA-N
Smiles O=C1C(C2=CC=C(F)C=C2)COC3=CC=CC=C31
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90β heterocomplexes, consequently blocking its function and inhibiting cancer cell motility.
  • Does not bind to Cdc37 or HSP90β alone.
  • Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer.
  • Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
Product References
  1. Precision therapeutic targeting of human cancer cell motility: L. Xu, et al.; Nat. Commun. 9, 2454 (2018)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.