AdipoGen Life Sciences


CHF 80.00
In stock
AG-CR1-3548-M01010 mgCHF 80.00
AG-CR1-3548-M05050 mgCHF 320.00
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Product Details
Synonyms 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]-benzenesulfonamide
Product Type Chemical


MW 343.4
CAS 200933-14-8
Purity Chemicals ≥98%
Appearance White to off-white solid.
Solubility Soluble in DMSO (10mg/ml) or ethanol (10mg/ml).
Identity Determined by 1H-NMR
InChi Key InChI=1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3
Smiles FC(F)(F)C1=CC=CC(NS(C2=C(C)C=C(C)C=C2C)(=O)=O)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Protect from moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • m-3M3FBS is a cell permeable and specific activator of phospholipase C (PLC) that has been shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2 and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase or PLD. m-3M3FBS also affects calcium homeostasis independently of PLC activation.
  • m-3M3FBS induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling.
  • m-3M3FBS has been shown in vitro to trigger mitochondrial damage and activate NLRP10 (a bona fide inflammasome binding to Asc and Caspase-1) in keratinocytes. NLRP10 acts also as inflammasome in intestine epithelial cells and protects against autoinflammation in the gut.
Product References
  1. Identification of a Compound That Directly Stimulates Phospholipase C Activity: Y-S. Bae, et al.; Mol. Pharmacol. 63, 1043 (2003)
  2. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation: J. Krjukova, et al.; Br. J. Pharmacol. 143, 3 (2004)
  3. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis: Y.-N. Lee, et al.; Cancer Lett. 222, 227 (2005)
  4. The novel phospholipase C activator, m-3M3FBS, induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling: E.M. Jung, et al.; Apoptosis 13, 133 (2008)
  5. Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis: S.D. Kim, et al.; J. Immunol. 189, 2000 (2012)
  6. Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons: S.A. Szebenyi, et al.; Front. Cell. Neurosci. 8, 336 (2014)
  7. Effect of 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzene-sulfonamide on calcium influx in three contraction models: E. Grzesk, et al.; Biomed. Rep. 4, 117 (2016)
  8. Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak: G. Quarato, et al.; Cell Death Differ. 29, 1318 (2022)
  9. Mitochondrial damage activates the NLRP10 inflammasome: T. Prochnicki, et al.; Nature Immunol. 24, 595 (2023)
  10. Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation: D. Zheng, et al.; Nature Immunol. 24, 585 (2023)
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