80 CHF CHF 80.00
AG-CR1-3548-M01010 mgCHF 80.00
AG-CR1-3548-M05050 mgCHF 320.00
|Appearance||White to off-white solid.|
|Solubility||Soluble in DMSO (10mg/ml) or ethanol (10mg/ml).|
|Identity||Determined by 1H-NMR|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light.
Protect from moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- m-3M3FBS is a cell permeable and specific activator of phospholipase C (PLC) that has been shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2 and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase or PLD. m-3M3FBS also affects calcium homeostasis independently of PLC activation.
- m-3M3FBS induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling.
- m-3M3FBS has been shown in vitro to trigger mitochondrial damage and activate NLRP10 (a bona fide inflammasome binding to Asc and Caspase-1) in keratinocytes. NLRP10 acts also as inflammasome in intestine epithelial cells and protects against autoinflammation in the gut.
- Identification of a Compound That Directly Stimulates Phospholipase C Activity: Y-S. Bae, et al.; Mol. Pharmacol. 63, 1043 (2003)
- Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation: J. Krjukova, et al.; Br. J. Pharmacol. 143, 3 (2004)
- The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis: Y.-N. Lee, et al.; Cancer Lett. 222, 227 (2005)
- The novel phospholipase C activator, m-3M3FBS, induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling: E.M. Jung, et al.; Apoptosis 13, 133 (2008)
- Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis: S.D. Kim, et al.; J. Immunol. 189, 2000 (2012)
- Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons: S.A. Szebenyi, et al.; Front. Cell. Neurosci. 8, 336 (2014)
- Effect of 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzene-sulfonamide on calcium influx in three contraction models: E. Grzesk, et al.; Biomed. Rep. 4, 117 (2016)
- Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak: G. Quarato, et al.; Cell Death Differ. 29, 1318 (2022)
- Mitochondrial damage activates the NLRP10 inflammasome: T. Prochnicki, et al.; Nature Immunol. 24, 595 (2023)
- Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation: D. Zheng, et al.; Nature Immunol. 24, 585 (2023)