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AdipoGen Life Sciences
m-3M3FBS
80
CHF
CHF 80.00
In stock
AG-CR1-3548-M01010 mgCHF 80.00
AG-CR1-3548-M05050 mgCHF 320.00
| Product Details | |
|---|---|
| Synonyms | 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]-benzenesulfonamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H16F3NO2S |
| MW | 343.4 |
| CAS | 200933-14-8 |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (10mg/ml) or ethanol (10mg/ml). |
| Identity | Determined by 1H-NMR |
| InChi Key | InChI=1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3 |
| Smiles | FC(F)(F)C1=CC=CC(NS(C2=C(C)C=C(C)C=C2C)(=O)=O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- m-3M3FBS is a cell permeable and specific activator of phospholipase C (PLC) that has been shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2 and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase or PLD. m-3M3FBS also affects calcium homeostasis independently of PLC activation.
- m-3M3FBS induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling.
- m-3M3FBS has been shown in vitro to trigger mitochondrial damage and activate NLRP10 (a bona fide inflammasome binding to Asc and Caspase-1) in keratinocytes. NLRP10 acts also as inflammasome in intestine epithelial cells and protects against autoinflammation in the gut.
Product References
- Identification of a Compound That Directly Stimulates Phospholipase C Activity: Y-S. Bae, et al.; Mol. Pharmacol. 63, 1043 (2003)
- Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation: J. Krjukova, et al.; Br. J. Pharmacol. 143, 3 (2004)
- The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis: Y.-N. Lee, et al.; Cancer Lett. 222, 227 (2005)
- The novel phospholipase C activator, m-3M3FBS, induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling: E.M. Jung, et al.; Apoptosis 13, 133 (2008)
- Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis: S.D. Kim, et al.; J. Immunol. 189, 2000 (2012)
- Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons: S.A. Szebenyi, et al.; Front. Cell. Neurosci. 8, 336 (2014)
- Effect of 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzene-sulfonamide on calcium influx in three contraction models: E. Grzesk, et al.; Biomed. Rep. 4, 117 (2016)
- Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak: G. Quarato, et al.; Cell Death Differ. 29, 1318 (2022)
- Mitochondrial damage activates the NLRP10 inflammasome: T. Prochnicki, et al.; Nature Immunol. 24, 595 (2023)
- Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation: D. Zheng, et al.; Nature Immunol. 24, 585 (2023)