CA77.1 [CMA Activator]

CHF 100.00
In stock
AG-CR1-0165-M0055 mgCHF 100.00
AG-CR1-0165-M02525 mgCHF 400.00
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Product Details
Synonyms N-[4-(6-Chloroquinoxalin-2-yl)phenyl]acetamide
Product Type Chemical
Properties
Formula

C16H12ClN3O

MW 297.7
CAS 2412270-22-3
Source/Host Chemicals Synthetic
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO (20mg/ml). Almost insoluble in other tested solvents, like MeOH, EtOH or water.
Identity Determined by 1H-NMR.
InChi Key ZQXMPDVGBWOTBY-UHFFFAOYSA-N
Smiles ClC1=CC=C(N=C(C2=CC=C(NC(C)=O)C=C2)C=N3)C3=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • CA77.1 is a novel selective chaperone-mediated autophagy (CMA) activator by increasing the expression of the lysosomal receptor for this pathway, LAMP2A, in lysosomes. Chaperone-mediated autophagy (CMA), is a selective autophagy shown to degrade neurodegeneration-related proteins such as α-synuclein (α-syn) or tau. Loss of neuronal CMA leads to altered neuronal function, selective changes in the neuronal metastable proteome and proteotoxicity. Chemical upregulation of CMA has been shown to ameliorate pathology in AD experimental mouse models, reduce brain pathology and improve disease phenotype.
  • CA77.1 is able to activate CMA in vitro and in vivo (in contrary to it's derivative AR7 which was not suitable for in vivo application). CA77.1 is able to activate CMA in vivo, and demonstrates brain penetrance and favorable pharmacokinetics. It has been shown in animal studies that administration of CA77.1 to enhance chaperone-mediated autophagy, may help to degrade toxic pathogenic protein products such as tau proteins and has potential applications in the treatment of Alzheimer's disease.
Product References
  1. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome: M. Bourdenx, et al.; Cell 184, (2021)
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