Forskolin

Specifications / Handling

More Information
Product Details
Synonyms	Boforsin; Colforsin; Coleonol; NSC 357088; NSC 375489
Product Type	Chemical
Properties
Formula	C₂₂H₃₄O₇
MW	410.5
Merck Index	14: 2476
CAS	66428-89-5 and 66575-29-9
Source/Host Chemicals	Isolated from Coleus forskohlii.
Purity Chemicals	≥98% (HPLC)
Appearance	White to off-white solid.
Solubility	Soluble in ethyl acetate, anhydrous DMSO or ethanol; very poorly soluble in water. DMSO is the recommended solvent for activation of cAMP.
Identity	Determined by ¹H-NMR.
Other Product Data	Note: Do not dissolve in ethanol for activation of adenylyl cyclase.
InChi Key	OHCQJHSOBUTRHG-KGGHGJDLSA-N
Smiles	[H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels [1, 2, 6].
Widely used tool to investigate cAMP as a second messenger [15].
Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator [3, 4, 6].
Glucose transporter inhibitor [4].
Platelet aggregation inhibitor [3, 10].
Stimulates lipolysis in fat cells [8].
Non-competitive nicotinic acetylcholine receptors inhibitor [9].
MAP kinase inhibitor [11].
Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue [12].
Autophagy inhibitor [13].
Hedgehog signaling inhibitor [14].
Has antiglaucoma potential [16].
Promotes neuronal differentiation of NSCs [17].
Anti-neuroinflammatory and neuroprotective agent. Ameliorated Alzheimer’s disease symptoms, restoring impairment in nesting ability and sociability, and reducing neuroinflammation and amyloid beta deposition [18].

Product References

The positive inotropic-acting forskolin, a potent adenylate cyclase activator: H. Metzger & E. Lindner; Arzneimittelforschung 31, 1248 (1981)
Forskolin: a unique diterpene activator of cyclic AMP-generating systems: K.B. Seamon & J.W. Daly; J. Cyclic Nucleotide Res. 7, 201 (1981)
Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties: N.J. de Souza, et al.; Med. Res. Rev. 3, 201 (1983)
Effects of forskolin on cerebral blood flow: Implications for a role of adenylate cyclase: D.G. Wysham, et al.; Stroke 17, 1299 (1986)
Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter: H.G. Joost & H.J. Steinfelder; Mol. Pharmacol. 31, 279 (1987)
Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle: A. Abe & H. Karaki; J. Pharmacol. Exp. Ther. 249, 895 (1989)
Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?: A. Laurenza, et al.; TIPS 10, 442 (1989) (Review)
Relationship between cyclic AMP production and lipolysis induced by forskolin in rat fat cells: H. Okuda, et al.; J. Lipid Res. 33, 225 (1992)
Forskolin acts as a noncompetitive inhibitor of nicotinic acetylcholine receptors: M.L. Aylwin & M.M. White; Mol. Pharmacol. 41, 908 (1992)
Forskolin inhibits platelet-activating factor binding to platelet receptors independently of adenylyl cyclase activation: S. Wong, et al.; Eur. J. Pharmacol. 245, 55 (1993)
Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts: S.R. Siddhanti, et al.; Endocrinol. 136, 4834 (1995)
Thermogenesis in brown adipose tissue with age: post-receptor activation by forskolin: P.J. Scarpace & M. Matheny; Pflugers Arch. 431, 388 (1996)
Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells: N. Canu, et al.; J. Neurochem. 92, 1228 (2005)
Forskolin, a Hedgehog signal inhibitor, inhibits cell proliferation and induces apoptosis in pediatric tumor cell lines: H. Yamanaka, et al.; Mol. Med. Rep. 3, 133 (2010)
Forskolin and derivatives as tools for studying the role of cAMP: R.H. Alasbahi & M.F. Melzig; Pharmazie 67, 5 (2012) (Review)
Forskolin: upcoming antiglaucoma molecule: V.D. Wagh, et al.; J. Postgrad. Med. 58, 199 (2012) (Review)
Functional neural differentiation of human adipose tissue-derived stem cells using bFGF and forskolin: S. Jang, et al.; BMC Cell Biol. 11, 1 (2010)
Protective effects of forskolin on behavioral deficits and neuropathological changes in a mouse model of cerebral amyloidosis: B.A. Owona, et al.; J. Neuropathol. Exp. Neurol. 75, 618 (2016)

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