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AdipoGen Life Sciences
Cytisine
30
CHF
CHF 30.00
In stock
AG-CN2-0075-M0055 mgCHF 30.00
AG-CN2-0075-M02525 mgCHF 65.00
| Product Details | |
|---|---|
| Synonyms | (-)-Cytisine; Baptitoxin; NSC 407282; BRN 0083882 |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H14N2O |
| MW | 190.2 |
| CAS | 485-35-8 |
| Source/Host Chemicals | Isolated from Laburnum anagyroides seeds. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in ethanol, benzene, acetone or ethyl acetate. Sparingly soluble in water or methanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | ANJTVLIZGCUXLD-DTWKUNHWSA-N |
| Smiles | O=C1C=CC=C2C3CNCC(C3)CN12 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Pyridine-like alkaloid.
- Nicotine agonist.
- Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors.
- Shows analgesic, antihypertensive and inotropic activities.
- Used for smoking cessation.
- Might be used for binge-like ethanol drinking cessation.
- Iron-chelator and hydroxyl radical scavanger.
- Has antidepressant properties.
- Used in forensics in novel surface molecular imprinting techniques.
Product References
- Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit: R.L. Papke & S.F. Heinemann; Mol. Pharmacol. 45, 142 (1994)
- Evidence for spare nicotinic acetylcholine receptors and a beta 4 subunit in bovine adrenal chromaffin cells: studies using bromoacetylcholine, epibatidine, cytisine and mAb35: B.W. Wenger, et al.; J. Pharmacol. Exp. Ther. 281, 905 (1997)
- Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo: B. Ferger, et al.; Eur. J. Pharmacol. 360, 155 (1998)
- Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors: L.M. Houlihan, et al.; J. Neurochem. 78, 1029 (2001)
- Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates: J. Zhang & J.H. Steinbach; Brain Res. 959, 98 (2003)
- Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes: Y.E. Slater, et al.; Neuropharmacology 44, 503 (2003)
- Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy: P. Tutka & W. Zatonski; Pharmacol. Rep. 58, 777 (2006) (Review)
- Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice: Y.S. Mineur, et al.; Neuropharmacology 52, 1256 (2007)
- Cytisine for smoking cessation: a research agenda: J.F. Etter, et al.; Drug Alcohol Depend. 92, 3 (2008) (Review)
- Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors: Y.F. Li, et al.; Auton. Neurosci. 154, 14 (2010)
- Preparation and recognition performance of cytisine alkaloid-imprinted material prepared using novel surface molecular imprinting technique: B. Gao, et al.; J. Sep. Sci. 33, 1338 (2010)
- Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice: R.K. Sajja & S. Rahman; Prog. Neuropsychopharmacol. Biol. Psychiatry 35, 257 (2011)
- Cytisine improves smoking cessation: W. Osman; Thorax 67, 573 (2011)
- Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors: E.G. Perez, et al.; Nat. Prod. Rep. 29, 555 (2012) (Review)
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