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AdipoGen Life Sciences
PD 150,606
95
CHF
CHF 95.00
In stock
AG-CR1-0066-M0055 mgCHF 95.00
AG-CR1-0066-M02525 mgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid |
| Product Type | Chemical |
| Properties | |
| Formula |
C9H7IO2S |
| MW | 306.1 |
| CAS | 426821-41-2 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | DJCVSFWGKYHMKH-YVMONPNESA-N |
| Smiles | OC(=O)C(\S)=C\C1=CC=C(I)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable and selective calpain-1 and -2 inhibitor [1, 3].
- Interacts with calcium-binding domain of calpain [2, 4].
- Neuroprotective [2].
- Ca2+-permeable AMPA receptor inhibitor [5].
- Apoptosis inhibitor [6]
- Autophagy activator by preventing cleavage of ATG5 [7.]
Product References
- Modulation of hypoxia-induced calpain activity in rat renal proximal tubules: C.L. Edelstein, et al.; Kidney Int. 50, 1150 (1996)
- An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective: K.K. Wang, et al.; PNAS 93, 6687 (1996)
- Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors: K.K. Wang, et al.; Adv. Exp. Med. Biol. 389, 95 (1996)
- Crystal structure of calcium bound domain VI of calpain at 1.9A resolution and its role in enzyme assembly, regulation, and inhibitor binding: G.D. Lin, et al.; Nat. Struct. Biol. 4, 539 (1997)
- An alpha-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition: L. Van den Bosch, et al.; Neuropharmacology 42, 706 (2002)
- Calpain, an upstream regulator of thymocyte apoptosis: M.K. Squier & J.J. Cohen; J. Immunol. 158, 3690 (1997)
- Post-translational control of IL-1β via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53: M. Niebler, et al.; PLoS Pathog. 9, e1003536 (2013)