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AdipoGen Life Sciences
Umbellulone
180
CHF
CHF 180.00
In stock
AG-CN2-0085-M01010 mgCHF 180.00
AG-CN2-0085-M100100 mgCHF 1'260.00
| Product Details | |
|---|---|
| Synonyms | (-)-Umbellulone; Umbellol; NSC 22046; BRN 2042730; Oreodaphnol; 3-Thujen-2-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H14O |
| MW | 150.2 |
| CAS | 546-78-1 |
| RTECS | XP0200000 |
| Source/Host Chemicals | Isolated from Umbellularia californica Nutt. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Colourless oil. |
| Solubility | Soluble in DMSO or ethanol. |
| Identity | Determined by 1H-NMR. |
| Other Product Data |
Density: 1.057 ± 0.06g/cm3(mL) Irritant: Umbellulone is a headache-inducing monoterpene ketone. Can induce headache when inhaling. Caution should be taken when dealing with this substance. |
| InChi Key | LTTVJAQLCIHAFV-UHFFFAOYSA-N |
| Smiles | CC(C)C12CC1C(C)=CC2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Offensive principle of the so-called "headache tree".
- Causes a painful cold sensation.
- Selective TRPA1 activator. Weak TRPM8 activator.
- Releases CGRP (calcitonin gene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine.
Product References
- Umbellulone modulates TRP channels: J. Zhong, et al.; Pflugers Arch. 462, 861 (2011)
- The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system: R. Nassini, et al.; Brain 135, 376 (2012)
- Activation of TRPA1 on dural afferents: a potential mechanism of headache pain: R.M. Edelmayer, et al.; Pain 153, 1949 (2012)
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