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AdipoGen Life Sciences
Imperatorin
45
CHF
CHF 45.00
In stock
AG-CN2-0084-M0011 mgCHF 45.00
AG-CN2-0084-M0055 mgCHF 75.00
AG-CN2-0084-M02525 mgCHF 120.00
| Product Details | |
|---|---|
| Synonyms | Pentosalen; Marmelosin; Ammidin; NSC 402949; BAN |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H14O4 |
| MW | 270.3 |
| Merck Index | 14: 4925 |
| CAS | 482-44-0 |
| RTECS | LV1575000 |
| Source/Host Chemicals | Isolated from Opopanax chironium L. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or dimethyl formamide. Slightly soluble in methanol or water. Insoluble in ethanol. |
| Identity | Determined by 1H-NMR |
| InChi Key | OLOOJGVNMBJLLR-UHFFFAOYSA-N |
| Smiles | CC(C)=CCOC1=C2OC(=O)C=CC2=CC2=C1OC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anticancer compound [1, 2, 10, 14].
- Apoptosis inducer. Induces DNA fragmentation at the G1/S phase of the cell cycle [1, 2, 14].
- HIV-1 replication inhibitor [3].
- Anti-inflammatory [4, 9, 11].
- Vasodilatation inducer [5].
- Increases BMP-2 expression (mRNA) and enhance bone formation [6].
- Modulator of SMAD1/5/8, p38, ERK pathways [6].
- Exerts anti-hypertrophic effects [7].
- Caspase-1 activity inhibitor in vivo and in vitro [8].
- Antibacterial and antilisteria compound [12].
- L-Type calcium channel blocker [13].
Product References
- Imperatorin, a furanocoumarin from Angelica dahurica (Umbelliferae), induces cytochrome c-dependent apoptosis in human promyelocytic leukaemia, HL-60 Cells: H.O. Pae, et al.; Pharmacol. Toxicol. 91, 40 (2002)
- Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin: G. Appendino, et al.; J. Nat. Prod. 67, 532 (2004)
- Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway: R. Sancho, et al.; J. Biol. Chem. 279, 37349 (2004)
- Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT: N. Marquez, et al.; Planta Med. 70, 1016 (2004)
- Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release: J. Y. He, et al.; Eur. J. Pharmacol. 573, 170 (2007)
- Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts: C.H.Tang, et al.; Eur. J. Pharmacol. 579, 40 (2008)
- Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases: F.D. Ivey, et al.; J. Biomol. Screen. 13, 62 (2008)
- Furanocoumarins-imperatorin inhibits myocardial hypertrophy both in vitro and in vivo: Y. Zhang, et al.; Fitoterapia 81, 1188 (2010)
- Distinct effects of imperatorin on allergic rhinitis: imperatorin inhibits caspase-1 activity in vivo and in vitro: H.A. Oh, et al.; J. Pharmacol. Exp. Ther. 339, 72 (2011)
- Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis: G.J. Huang, et al.; J. Agric. Food Chem. 60, 1673 (2012)
- Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways: K.W. Luo, et al.; Chemotherapy 57, 449 (2011)
- Imperatorin Attenuates LPS-Induced Inflammation by Suppressing NF-κB and MAPKs Activation in RAW 264.7 Macrophages: W. Guo, et al.; Inflammation 35, 1764 (2012)
- Antilisterial potential of imperatorin and limonin from poncirus trifoliata rafin: A. Rahman, et al.; J. Food Biochem. 36, 217 (2012)
- Structural Modeling and Identification of Imperatorin as Novel L-Type Calcium Channel Blocker: W. Lu, et al.; Med. Chem. 9, 993 (2013)
- Imperatorin sensitizes anoikis and inhibits anchorage-independent growth of lung cancer cells: K. Choochuay, et al.; J. Nat. Med. 67, 599 (2013)
- Imperatorin–pharmacological meaning and analytical clues: profound investigation: E. Koziol & K. Skalicka-Wozniak; Phytochem. Rev. 15, 627 (2016)
- Imperatorin possesses notable anti‑inflammatory activity in vitro and in vivo through inhibition of the NF‑κB pathway: X. Zhang, et al.; Mol. Med. Rep. 16, 8619 (2017)
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