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BioViotica
Mensacarcin
155
CHF
CHF 155.00
In stock
BVT-0028-M0011 mgCHF 155.00
BVT-0028-M0055 mgCHF 470.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula |
C21H24O9 |
| MW | 420.4 |
| CAS | 808750-39-2 |
| Source/Host Chemicals | Isolated from Streptomyces bottropensis. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | WWNXYRCJJRRWAQ-UJLZTCEPSA-N |
| Smiles | CO[C@H]1C2=C(OC)C=CC=C2C(=O)[C@@]23O[C@@]12[C@@H](O)[C@@](O)([C@@H](C)[C@H]3O)C(=O)[C@@H]1O[C@H]1C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic. Cytotoxic.
- Antitumor compound. Anti-melanoma drug lead compound. Effective in BRAF V600E mutation cell lines.
- Potently induces apoptosis in melanoma cells. Localizes to mitochondria, affects energy metabolism in mitochondria rapidly and activates caspase-3/7-dependent apoptotic pathways.
- Inhibits cell growth in a borad range of human cancer cell lines. Shows cell type specificity inducing strong cytostasis most effective in cancer types with low oxygen respiration ratios like melanomas.
Product References
- Towards a total synthesis of the new anticancer agent mensacarcin: synthesis of the carbocyclic core: L.F. Tietze, et al.; Chemistry 10, 5233 (2004)
- Cloning and heterologous expression of three type II pks gene clusters from Streptomyces bottropensis: X. Yan, et al.; ChemBioChem 13, 224 (2012)
- Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8: S. Maier, et al.; ChemBioChem 15, 749 (2014)
- Functional Characterization of Different ORFs Including Luciferase-Like Monooxygenase Genes from the Mensacarcin Gene Cluster: S. Maier, et al.; ChemBioChem 16, 1175 (2015)
- The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells: B. Plitzko, et al.; J. Biol. Chem. 292, 21102 (2017)
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