Seriniquinone

CHF 70.00
In stock
BVT-0478-M0011 mgCHF 70.00
BVT-0478-M0055 mgCHF 210.00
BVT-0478-M01010 mgCHF 370.00
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Product Details
Synonyms Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13(5aH,12bH)-tetraone
Product Type Chemical
Properties
Formula

C20H8O4S

MW 344.3
CAS 22200-69-7
Source/Host Chemicals Synthetic. Originally isolated from marine bacterium Serinicoccus sp. strain CNJ927.
Purity Chemicals ≥99% (HPLC)
Appearance Yellow to orange solid.
Solubility Soluble in DMSO (10mg/ml) or DMF (15mg/ml). Insoluble in water.
Identity Determined by 1H-NMR and 13C-NMR.
Declaration Manufactured by BioViotica.
InChi Key XYWAAJHFTBPXOA-UHFFFAOYSA-N
Smiles O=C1C(C(C2C3=O)C(C4=C3C=CC=C4)=O)=C(S2)C(C5=CC=CC=C51)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Stock solutions are stable for at least 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Seriniquinone is a potent cytotoxic and melanoma-selective anticancer agent. Upon cellular treatment and based on the compounds fluorescent nature it was found localized in the endoplasmic reticulum.
  • Seriniquinone inhibits cell proliferation marked by autophagocytosis and induces cell death due to caspase-9 dependent apoptosis. Mode of action studies suggest that it specifically targets a skin protective antimicrobial peptide dermcidin (DCD), whose role as a cancer-protective protein has been recently recognized.
Product References
  1. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin: L. Trzoss, et al.; PNAS 111, 14687 (2014)
  2. Mass spectrometry analysis of protonated marine natural product seriniquinone: R.M. da Silva, et al.; J. Braz. Chem. Soc. 29, 1162 (2018)
  3. Advance of Seriniquinone Analogues as Melanoma Agents: J.C. Hammons, et al.; ACS Med. Chem. Lett. 10, 186 (2019)
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