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BioViotica
Seriniquinone
70
CHF
CHF 70.00
In stock
BVT-0478-M0011 mgCHF 70.00
BVT-0478-M0055 mgCHF 215.00
BVT-0478-M01010 mgCHF 385.00
| Product Details | |
|---|---|
| Synonyms | Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13(5aH,12bH)-tetraone |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H8O4S |
| MW | 344.3 |
| CAS | 22200-69-7 |
| Source/Host Chemicals | Synthetic. Originally isolated from marine bacterium Serinicoccus sp. strain CNJ927. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | Yellow to orange solid. |
| Solubility | Soluble in DMSO (10mg/ml) or DMF (15mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR and 13C-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | PWUWIMAXHCTYJA-UHFFFAOYSA-N |
| Smiles | O=C1C(C2=C3C(C4=C(C2=O)C=CC=C4)=O)=C(S3)C(C5=CC=CC=C51)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Protect from light. Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for at least 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Seriniquinone is a potent cytotoxic and melanoma-selective anticancer agent. Upon cellular treatment and based on the compounds fluorescent nature it was found localized in the endoplasmic reticulum.
- Seriniquinone inhibits cell proliferation marked by autophagocytosis and induces cell death due to caspase-9 dependent apoptosis. Mode of action studies suggest that it specifically targets a skin protective antimicrobial peptide dermcidin (DCD), whose role as a cancer-protective protein has been recently recognized.
Product References
- Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin: L. Trzoss, et al.; PNAS 111, 14687 (2014)
- Mass spectrometry analysis of protonated marine natural product seriniquinone: R.M. da Silva, et al.; J. Braz. Chem. Soc. 29, 1162 (2018)
- Advance of Seriniquinone Analogues as Melanoma Agents: J.C. Hammons, et al.; ACS Med. Chem. Lett. 10, 186 (2019)
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