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AdipoGen Life Sciences
Dermcidin-1L (human) . TFA
180
CHF
CHF 180.00
In stock
AG-CP3-0039-M0011 mgCHF 180.00
AG-CP3-0039-M0055 mgCHF 540.00
| Product Details | |
|---|---|
| Synonyms | DCD-1L; Proteolysis-inducing Factor; Survival-promoting Peptide |
| Product Type | Chemical |
| Properties | |
| Formula |
C210H359N57O71 . C2HF3O2 |
| MW | 4818.5 . 114.0 |
| Sequence |
H-Ser-Ser-Leu-Leu-Glu-Lys-Gly-Leu-Asp-Gly-Ala-Lys-Lys-Ala-Val-Gly-Gly-Leu-Gly-Lys-Leu-Gly-Lys-Asp-Ala-Val-Glu-Asp-Leu-Glu-Ser-Val-Gly-Lys-Gly-Ala-Val-His-Asp-Val-Lys-Asp-Val-Leu-Asp-Ser-Val-Leu-OH trifluoroacetate salt |
| CAS | 478898-18-9 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥95% |
| Appearance | Solid lyophilized powder. |
| Solubility | Soluble in water (1mg/ml). |
| Crossreactivity | Human |
| InChi Key | DBFODOQWDMTJRA-KPEYATPJSA-N |
| Smiles | N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)CC(O)=O)=O)CC1=CN=CN1)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)C)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)C)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Dermcidin is an antimicrobial peptide constitutively expressed in sweat glands, secreted into the sweat and transported to the epidermal surface. In sweat it is proteolytically processed to Dermcidin-1L (DCD-1L) that has antimicrobial activity against a variety of pathogenic microorganisms and other peptides (e.g. DCD-1, Y-P30).
-
Dermcidin-1L (DCD-1L) is a 48aa antimicrobial peptide (AMP) with a Leu residue on the C-terminus, secreted in sweat and part of the innate host defense of the immune system. Unlike most AMPs, which are cationic, DCD-1L has a net negative charge. DCD-1L displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans.
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DCD-1L is first monomeric in human sweat. DCD-1L interaction with negatively charged bacterial membrane phospholipids leads to Zn(2+) dependent formation of oligomeric DCD-1L complexes in the bacterial membrane, which subsequently leads to ion channel formation resulting in membrane depolarization and bacterial cell death.
-
The gene products of DCD have been reported to be a neuronal survival factor, a putative oncogene in breast cancer and a proteolysis-inducing factor (PIF) that induces skeletal muscle proteolysis to cause cancer cachexia.
Product References
- Dermcidin: a novel human antibiotic peptide secreted by sweat glands: B. Schittek, et al.; Nat. Immunol. 2, 1133 (2001)
- Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions: S. Rieg, et al.; Br. J. Dermatol. 151, 534 (2004)
- Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide: Y.P. Lai, et al.; BBRC 328, 243 (2005)
- Antimicrobial peptides: effectors of innate immunity in the skin: O. Barak, et al.; Adv. Dermatol. 21, 357 (2005) (Review)
- Naturally processed dermcidin-derived peptides do not permeabilize bacterial membranes and kill microorganisms irrespective of their charge: H. Steffen, et al.; Antimicrob. Agents Chemother. 50, 2608 (2006)
- Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity: J.P. Lee Motoyama, et al.; BBRC 357, 828 (2007)
- The dermcidin gene in cancer: role in cachexia, carcinogenesis and tumour cell survival: G.D. Stewart, et al.; Curr. Opin. Clin. Nutr. Metab. Care 11, 208 (2008) (Review)
- The multiple facets of dermcidin in cell survival and host defense: B. Schittek; J. Innate Immun. 4, 349 (2012) (Review)
- Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin: L. Trzoss, et al.; PNAS 111, 14687 (2014)
- The secrets of dermcidin action: M. Burian & B. Schittek; Int. J. Med. Microbiol. 305, 283 (2015) (Review)
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