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BioViotica
Pseurotin D
145
CHF
CHF 145.00
In stock
BVT-0426-M0011 mgCHF 145.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula |
C22H25NO8 |
| MW | 431.4 |
| CAS | 77409-68-8 |
| Source/Host Chemicals | Isolated from Aspergillus fumigatus. |
| Purity Chemicals | ≥98% (HPLC, NMR) |
| Appearance | Off-white to beige solid. |
| Solubility | Soluble in DMSO, chloroform or dichloromethane. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | GZAYJWNDYQINEI-OLSIJDASSA-N |
| Smiles | CC1=C([C@@H](O)/C=C/C(O)CC)O[C@@]2([C@@H](O)[C@](OC)(C(C3=CC=CC=C3)=O)NC2=O)C1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Isomeric to pseurotin A (Prod. No. BVT-0003).
- Anticancer and antiparasitic compound.
- Apomorphine antagonist. Neuroleptic agent.
- Inhibitor of IgE production.
- Decreases ovalbumin-induced foot pad edema in vivo.
- Inhibits activation of B-cells and differentiation into the plasma cells.
- Apoptosis inducer.
Product References
- Pseurotin B, C, D and E. Further new metabolites of Pseudeurotium ovalis STOLK: W. Breitenstein et al.; Helv. Chim. Acta 64, 379 (1981)
- Biologically active pseurotins A and D, new metabolites from Aspergillus fumigates, process for their preparation and their use as apomorphine antagonist: J. Wink, et al.; Eur. Pat. Appl. EP546475A1 (1993)
- Pseurotin A and its analogues as inhibitors of immunoglobulin E production: M. Ishikawa, et al.; Bioorg. Med. Chem. Lett. 19, 1457 (2009)
- Antitumor compositions containing pseurotin D: D. G. Kim, et al.; Repub. Korean Kongkae aeho Kongbo KR20110087395 (2011)
- Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544: S. Martinez-Luis, et al.; Nat. Prod. Comm. 7, 165 (2012)
- Elucidation of Pseurotin Biosynthetic Pathway Points to Trans-Acting C-Methyltransferase: Generation of Chemical Diversity: Y. Tsunematsu, et al.; Angew. Chem. Int. Ed. 53, 8475 (2014)
- Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195: M.-S. Lee, et al.; J. Nat. Prod. 79, 2983 (2016)
- Treatment of epilepsy using pseurotins and azaspirofurans: D. Copmans, et al.; PCT Int. Appl., WO 2019043019 A1 20190307 (2019)
- Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells: O. Vasicek, et al.; Phytomedicine in press (2020)
- Pseurotin D Induces Apoptosis through Targeting Redox Sensitive Pathways in Human Lymphoid Leukemia Cells: E. Mosejova, et al.; Antioxidants 10, 1576 (2021)
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