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AdipoGen Life Sciences
Z-VRPR-FMK
490
CHF
CHF 490.00
In stock
AG-CP3-0008-C500500 µgCHF 490.00
AG-CP3-0008-M0011 mgCHF 500.00
| Product Details | |
|---|---|
| Synonyms | Z-Val-Arg-Pro-DL-Arg-FMK . TFA; MALT1 Inhibitor |
| Product Type | Chemical |
| Properties | |
| Formula |
C31H49FN10O6 . C2HF3O2 |
| MW | 676.8 . 114.0 |
| Sequence |
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone |
| CAS | 1381885-28-4 (free base) |
| Purity Chemicals | ≥90% (HPLC) |
| Appearance | White to slightly yellow solid. |
| Solubility | Soluble in water (1mg/ml). |
| Identity | Determined by MS. |
| InChi Key | DYQKGOBRZWMAHV-YTJMMMLMSA-N |
| Smiles | OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Hygroscopic. Protect from moisture. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective cell permeable and irreversible MALT1 inhibitor.
- Inhibits NF-κB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines.
- Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.
Product References
- The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008)
- Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma: S. Hailfinger, et al.; PNAS 106,19947 (2009)
- Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2: S.I. Gringhuis, et al.; PLoS Pathogens 7, e1001259 (2011)
- Crystal structure of a Trypanosoma brucei metacaspase: K. McLuskey, et al.; PNAS 109, 7469 (2012)
- MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo: L. Fontan, et al.; Cancer Cell 22, 812 (2012)
- The protease activity of the paracaspase MALT1 is controlled by monoubiquitination: C. Pelzer, et al.; J. Immunol. 14, 337 (2012)
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