AdipoGen Life Sciences

Herbimycin A

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AG-CN2-0429-C100100 µgCHF 180.00

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Product Details
Synonyms	Antibiotic TAN 420F; (15R)-17-Demethoxy-15-methoxy-11-O-methyl-geldanamycin
Product Type	Chemical
Properties
Formula	C₃₀H₄₂N₂O₉
MW	574.7
CAS	70563-58-5
RTECS	MK3830000
Source/Host Chemicals	Isolated from Streptomyces sp.
Purity Chemicals	≥99% (HPLC)
Appearance	Yellow solid.
Solubility	Soluble in ethanol, methanol DMSO or dimethylformamide. Poorly soluble in water.
InChi Key	MCAHMSDENAOJFZ-JZYYMJJSSA-N
Smiles	CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light. Protect from light when in solution.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Benzoquinone ansamycin antibiotic.
Herbicidal compound.
Potent, selective, irreversible and cell permeable protein tyrosine kinase inhibitor.
Inhibitor of v-Src, Yes, Fps, Ros, Bcr-Abl and ErbB oncogene products.
Antitumor compound.
Antiangiogenic. Inhibits NF-κB activation and phosphorylation of phospholipase C-γ1.
Inhibitor of heat shock protein 90 (Hsp90). Binds Hsp90 and destabilizes client proteins leading to their ubiquitination and proteasomal degradation.
Increases the sensitivity of certain cancer cells to chemotherapeutic agents.
Neuroprotective.
Antiparasitic, antischistosomal agent.
Antiviral.
Increase microtubules sensitivity to cold in plants.

Product References

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