MI-2 [MALT1 Inhibitor]

CHF 120.00
In stock
AG-CR1-3661-M0055 mgCHF 120.00
AG-CR1-3661-M02525 mgCHF 480.00
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Product Details
Synonyms 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide; ALB-H03200218
Product Type Chemical
Properties
Formula

C19H17Cl3N4O3

MW 455.7
CAS 1047953-91-2
Purity Chemicals ≥98%
Appearance White to off-white solid.
Solubility Soluble in DMSO (30mg/ml) or ethanol (5mg/ml).
InChi Key TWJGQZBSEMDPQP-UHFFFAOYSA-N
Smiles COCCOC1=NN(C2=CC=C(NC(CCl)=O)C=C2)C(C3=CC=C(Cl)C(Cl)=C3)=N1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Highly potent and selective irreversible MALT1 inhibitor (IC50=5.8μM). Binds directly to MALT1 and suppresses protease function.
  • Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 (EC50= ~200nM and ~500nM for HBL-1 and TMD8, respectively) activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines in vitro and xenotransplanted mouse ABC-DLBCL tumors in vivo and primary human ABC-DLBCLs ex vivo.
  • In combination with bryostatin 1 displays selective killing of HIV latently infected CD4+ T cells.
  • Inhibits NF-κB and NLRP3 inflammasome activation in macrophages. Decreased production of IL-1β/IL-18 in PMA-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-κB and NLRP3 inflammasome.
Product References
  1. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo: L. Fontan, et al.; Cancer Cell 22, 812 (2012)
  2. MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation: W. Liu, et al.; Oncotarget 7, 30536 (2016)
  3. Short Communication: Preferential Killing of HIV Latently Infected CD4(+) T Cells by MALT1 Inhibitor: H. Li, et al.; AIDS Res. Hum. Retroviruses 32, 174 (2016)
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